Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake
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DOI: 10.1002/glia.23279
Abstract: Accumulating evidence indicates that motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a non‐cell‐autonomous process and that impaired glutamate clearance by astrocytes, leading to excitotoxicity, could participate in progression of the disease. In astrocytes… read more here.
Keywords: glutamate uptake; glutamate; mglur5 activation; regulation glutamate ... See more keywords