Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Brain"
DOI: 10.1186/s13041-019-0441-8
Abstract: Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved exposing mice to highly stressful conditions including electric foot shocks… read more here.
Keywords: rodent touchscreen; flexibility; stress; mglur5 mice ... See more keywords
Analysis of the Gut Microbiota and Inflammatory Factors in mGluR5-Knockout Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2020.00335
Abstract: Introduction Accumulating evidence indicates that the glutamatergic system plays an important role in the development of depression. Notably, the antidepressant effect of metabotropic glutamate receptor 5 (mGluR5) modulation is inconsistent across studies. Here, we attempted… read more here.
Keywords: mglur5 mice; inflammatory factors; gut microbiota; mice ... See more keywords