In silico profiling and structural insights of zinc metal ion on O6-methylguanine methyl transferase and its interactions using molecular dynamics approach
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DOI: 10.1007/s00894-020-04631-x
Abstract: O6-methylguanine DNA methyl transferase (MGMT) is a metalloenzyme participating in the repair of alkylated DNA. In this research, we performed a comparative study for evaluating the impact of zinc metal ion on the behavior and… read more here.
Keywords: pcna; dna; apo mgmt; mgmt ... See more keywords
Characterization of MGMT and EGFR protein expression in glioblastoma and association with survival
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DOI: 10.1007/s11060-019-03358-x
Abstract: Purpose Understanding the molecular landscape of glioblastoma (GBM) is increasingly important in the age of targeted therapy. O-6-Methylguanine-DNA methyltransferase ( MGMT ) promoter methylation and EGFR amplification are markers that may play a role in… read more here.
Keywords: protein expression; mgmt; egfr protein; expression ... See more keywords
Prognostic and predictive impact of MGMT promoter methylation status in high risk grade II glioma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-022-03955-3
Abstract: MGMT promoter methylation has been associated with favorable prognosis and survival outcomes in patients with glioblastoma and WHO grade III glioma. However, the effects of promoter methylation of MGMT in patients with WHO grade II… read more here.
Keywords: methylation; grade glioma; prognostic predictive; mgmt ... See more keywords
Refining the selection of patients with metastatic colorectal cancer for treatment with temozolomide using proteomic analysis of O6-methylguanine-DNA-methyltransferase.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.11.016
Abstract: BACKGROUND The repair enzyme O6-methylguanine-DNA-methyltransferase (MGMT) is a validated predictor of benefit from temozolomide (TMZ) in glioblastoma. However, only 10% of patients with MGMT-methylated metastatic colorectal cancer (mCRC) respond to TMZ. METHODS Archived tumour samples… read more here.
Keywords: metastatic colorectal; methylguanine dna; mgmt; colorectal cancer ... See more keywords
The utilization of MGMT promoter methylation testing in United States hospitals for glioblastoma and its impact on prognosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2018.02.009
Abstract: Multiple studies have identified O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status to be an important prognostic factor in glioblastoma (GBM). We used the National Cancer Data Base (NCDB) to analyze completeness of coding for MGMT as… read more here.
Keywords: status; mgmt; mgmt promoter; promoter methylation ... See more keywords
Prognostic and predictive impact of MGMT promoter methylation in grade 3 gliomas
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DOI: 10.1016/j.jocn.2020.12.028
Abstract: BACKGROUND Grade 3 gliomas are aggressive primary brain tumors. Promoter methylation of methyl guanine methyl transferase (MGMT) has been associated with a favorable prognosis in patients with glioblastoma, but the impact of MGMT promoter methylation… read more here.
Keywords: methylation; grade glioma; mgmt; promoter methylation ... See more keywords
Machine learning-based radiomic, clinical and semantic feature analysis for predicting overall survival and MGMT promoter methylation status in patients with glioblastoma.
Sign Up to like & getrecommendations! Published in 2020 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2020.09.017
Abstract: INTRODUCTION Survival varies in patients with glioblastoma due to intratumoral heterogeneity and radiomics/imaging biomarkers have potential to demonstrate heterogeneity. The objective was to combine radiomic, semantic and clinical features to improve prediction of overall survival… read more here.
Keywords: status; patients glioblastoma; mgmt promoter; mgmt ... See more keywords
Predicting O6-Methylguanine-DNA Methyltransferase Protein Expression in Primary Low- and High-Grade Gliomas Using Certain Qualitative Characteristics of Amide Proton Transfer-Weighted Magnetic Resonance Imaging.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.05.100
Abstract: OBJECTIVE To demonstrate that certain qualitative amide proton transfer-weighted (APTw) characteristics can provide practical imaging clues for predicting O6-methylguanine-DNA methyltransferase (MGMT) protein expression in primary low- and high-grade gliomas, preoperatively and noninvasively. METHODS Pathologically confirmed… read more here.
Keywords: protein expression; high grade; mgmt; low high ... See more keywords
P14.36 Treatment patterns by O6-methylguanine DNA methyltransferase promoter (MGMT) status in newly-diagnosed glioblastoma multiforme (GBM): a multi-country chart review study
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.271
Abstract: This study explored the relationship between MGMT testing and treatment patterns of patients with newly-diagnosed GBM from France, Germany, Italy, Spain, the UK (EU5), and Canada. Medical oncologists and neuro-oncologists across EU5 and Canada completed… read more here.
Keywords: gbm; mgmt; less likely; likely receive ... See more keywords
MGMT methylation correlates with melphalan pelvic perfusion survival in stage III melanoma patients: a pilot study
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DOI: 10.1097/cmr.0000000000000367
Abstract: Approximately 25% of melanoma patients with locoregional metastases are nonresponsive to new molecular target therapy and immunotherapy. When metastases are located in the pelvis, melphalan hypoxic perfusion can be an optional treatment. Because methylation of… read more here.
Keywords: methylation; stage iii; mgmt; melanoma patients ... See more keywords
Prognostic value of O‐6‐methylguanine–DNA methyltransferase (MGMT) protein expression in glioblastoma excluding nontumour cells from the analysis
Sign Up to like & getrecommendations! Published in 2018 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12415
Abstract: It is important to predict response to treatment with temozolomide (TMZ) in glioblastoma (GBM) patients. Both MGMT protein expression and MGMT promoter methylation status have been reported to predict the response to TMZ. We investigated… read more here.
Keywords: mgmt protein; protein expression; glioblastoma; prognostic value ... See more keywords