Temozolomide-induced myelotoxicity and single nucleotide polymorphisms in the MGMT gene in patients with adult diffuse glioma: a single-institutional pharmacogenetic study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-022-03944-6
Abstract: Nearly 10% of patients with adult diffuse glioma develop clinically significant myelotoxicity while on temozolomide (TMZ) leading to treatment interruptions. This study aimed to assess single nucleotide polymorphisms (SNPs) in the O6-methylguanine-DNA methyltransferase (MGMT) gene… read more here.
Keywords: diffuse glioma; patients adult; mgmt gene; induced myelotoxicity ... See more keywords
Genosensor made with a self-assembled monolayer matrix to detect MGMT gene methylation in head and neck cancer cell lines.
Sign Up to like & getrecommendations! Published in 2020 at "Talanta"
DOI: 10.1016/j.talanta.2019.120609
Abstract: DNA methylation is involved in the oncogenesis of head and neck squamous cell carcinoma and could be used for early detection of cancer to increase the chances of cure, but unfortunately diagnosis is usually made… read more here.
Keywords: methylation; cell lines; mgmt gene; cell ... See more keywords
Promoter hypermethylation of MGMT gene may contribute to the pathogenesis of gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006708
Abstract: Beckground: The association of MGMT (O6-methyguanine deoxyribonucleic acid methyltransferase) promoter hypermethylation with gastric cancer (GC) risk has been studied extensively, but the results remained unclear. Here, we performed a meta-analysis to evaluate whether promoter hypermethylation… read more here.
Keywords: promoter hypermethylation; mgmt gene; promoter;
Identifying genetic variants regulating MGMT gene expression - A study in monozygotic Danish twins.
Sign Up to like & getrecommendations! Published in 2023 at "Genomics"
DOI: 10.2139/ssrn.4329759
Abstract: Identifying genetic factors affecting the regulation of the O-6-Methylguanine-DNA Methyltransferase (MGMT) gene and estimating the genetic contribution of the MGMT gene through within-pair correlation in monozygotic twin pairs is of particular importance in various types… read more here.
Keywords: expression; mgmt gene; gene; study ... See more keywords
Detection of a Double-Stranded MGMT Gene Using Electrochemically Reduced Graphene Oxide (ErGO) Electrodes Decorated with AuNPs and Peptide Nucleic Acids (PNA)
Sign Up to like & getrecommendations! Published in 2022 at "Biosensors"
DOI: 10.3390/bios12020098
Abstract: The ability to detect double-stranded DNA (dsDNA) as a biomarker without denaturing it to single-stranded DNA (ss-DNA) continues to be a major challenge. In this work, we report a sandwich biosensor for the detection of… read more here.
Keywords: double stranded; ergo; dna; mgmt gene ... See more keywords
Evaluation of MGMT Gene Methylation in Neuroendocrine Neoplasms
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DOI: 10.3727/096504021x16214197880808
Abstract: Unresectable neuroendocrine neoplasms (NENs) often poorly respond to standard therapeutic approaches. Alkylating agents, in particular temozolomide, commonly used to treat high-grade brain tumors including glioblastomas, have recently been tested in advanced or metastatic NENs, where… read more here.
Keywords: neuroendocrine neoplasms; methylation; evaluation mgmt; mgmt methylation ... See more keywords