Predictive modeling with linear machine learning can estimate glioblastoma survival in months based solely on MGMT-methylation status, age and sex
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-025-06441-7
Abstract: Machine Learning (ML) has become an essential tool for analyzing biomedical data, facilitating the prediction of treatment outcomes and patient survival. However, the effectiveness of ML models heavily relies on both the choice of algorithms… read more here.
Keywords: age; methylation; machine learning; methylation status ... See more keywords
Molecular genetic profiling reveals novel association between FLT3 mutation and survival in glioma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03567-9
Abstract: Recent molecular characterization of gliomas has uncovered somatic gene variation and DNA methylation changes that are associated with etiology, prognosis, and therapeutic response. Here we describe genomic profiling of gliomas assessed for associations between genetic… read more here.
Keywords: methylation; novel association; flt3 mutation; mgmt methylation ... See more keywords
Imaging Findings of New Entities and Patterns in Brain Tumor: Isocitrate Dehydrogenase Mutant, Isocitrate Dehydrogenase Wild-Type, Codeletion, and MGMT Methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Radiologic clinics of North America"
DOI: 10.1016/j.rcl.2021.01.001
Abstract: Molecular features are now essential in distinguishing between glioma histologic subtypes. Currently, isocitrate dehydrogenase mutation, 1p19q codeletion, and MGMT methylation status play significant roles in optimizing medical and surgical treatment. Noninvasive pretreatment and post-treatment determination… read more here.
Keywords: codeletion mgmt; dehydrogenase; isocitrate dehydrogenase; imaging findings ... See more keywords
Deep learning classification of MGMT status of glioblastomas using multiparametric MRI with a novel domain knowledge augmented mask fusion approach
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DOI: 10.1038/s41598-025-87803-0
Abstract: We aimed to build a robust classifier for the MGMT methylation status of glioblastoma in multiparametric MRI. We focused on multi-habitat deep image descriptors as our basic focus. A subset of the BRATS 2021 MGMT… read more here.
Keywords: mgmt methylation; methylation status; status; mri ... See more keywords
PATH-62. QUANTITATIVE ANALYSIS OF SEX-ASSOCIATED MGMT METHYLATION IN NEWLY DIAGNOSED GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.657
Abstract: Glioblastoma (GBM) and MGMT have been reported to have sexual dimorphism. In multiple studies, including our own population-based cohort analysis, females had higher rates of MGMT methylation and improved methylation-associated progression-free and overall survival outcomes… read more here.
Keywords: methylation; higher rates; compared males; newly diagnosed ... See more keywords
Clinical validation of a novel quantitative assay for the detection of MGMT methylation in glioblastoma patients
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Epigenetics"
DOI: 10.1186/s13148-021-01044-2
Abstract: Background The promoter hypermethylation of the methylguanine-DNA methyltransferase gene is a frequently used biomarker in daily clinical practice as it is associated with a favorable prognosis in glioblastoma patients treated with temozolamide. Due to the… read more here.
Keywords: mgmt methylation; methodology; glioblastoma patients; glioblastoma ... See more keywords
Beyond invasive biopsies: using VASARI MRI features to predict grade and molecular parameters in gliomas
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DOI: 10.1186/s40644-023-00638-8
Abstract: Background Gliomas present a significant economic burden and patient management challenge. The 2021 WHO classification incorporates molecular parameters, which guide treatment decisions. However, acquiring these molecular data involves invasive biopsies, prompting a need for non-invasive… read more here.
Keywords: mri; vasari mri; idh mutation; mgmt methylation ... See more keywords
Exploiting DNA repair alterations in metastatic pancreatic cancer (mPAC): Is MGMT methylation a new therapeutic target?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e15770
Abstract: e15770 Background: Metastatic pancreatic cancer (mPAC) has a poor prognosis, with few therapeutic options and an overall survival (OS) at 5 years < 5%. O6-methylguanine-DNA methyltransferase ( MGMT) is a key DNA repair gene, responsible… read more here.
Keywords: dna repair; mgmt; cancer; methylation ... See more keywords
Defining the prognostic role of MGMT methylation value by pyrosequencing assay in glioblastoma patients: A large Italian multicenter study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.2539
Abstract: 2539Background: MGMT methylation (MGMTmet) status represents an important prognostic factor for glioblastoma (GBM) patients (PTS). Quantitative pyrosequencing approach has proven to be feasible for... read more here.
Keywords: methylation; glioblastoma; prognostic role; defining prognostic ... See more keywords
Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma
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DOI: 10.3390/cancers15051384
Abstract: Simple Summary MGMT-methylated glioblastomas have significantly lower ADC values, as compared to the glioblastomas with no MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions… read more here.
Keywords: methylation status; methylation; mgmt methylation; adc values ... See more keywords
Radiomics and AI-Based Prediction of MGMT Methylation Status in Glioblastoma Using Multiparametric MRI: A Hybrid Feature Weighting Approach
Sign Up to like & getrecommendations! Published in 2025 at "Diagnostics"
DOI: 10.3390/diagnostics15101292
Abstract: Background/Objectives: Glioblastoma (GBM) is a highly aggressive primary central nervous system tumor with a median survival of 14 months. MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation status is a key biomarker as a prognostic indicator and a… read more here.
Keywords: mgmt methylation; mri; status; methylation status ... See more keywords