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Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03567-9
Abstract: Recent molecular characterization of gliomas has uncovered somatic gene variation and DNA methylation changes that are associated with etiology, prognosis, and therapeutic response. Here we describe genomic profiling of gliomas assessed for associations between genetic…
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Keywords:
methylation;
novel association;
flt3 mutation;
mgmt methylation ... See more keywords
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Published in 2021 at "Radiologic clinics of North America"
DOI: 10.1016/j.rcl.2021.01.001
Abstract: Molecular features are now essential in distinguishing between glioma histologic subtypes. Currently, isocitrate dehydrogenase mutation, 1p19q codeletion, and MGMT methylation status play significant roles in optimizing medical and surgical treatment. Noninvasive pretreatment and post-treatment determination…
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Keywords:
codeletion mgmt;
dehydrogenase;
isocitrate dehydrogenase;
imaging findings ... See more keywords
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Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.657
Abstract: Glioblastoma (GBM) and MGMT have been reported to have sexual dimorphism. In multiple studies, including our own population-based cohort analysis, females had higher rates of MGMT methylation and improved methylation-associated progression-free and overall survival outcomes…
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Keywords:
methylation;
higher rates;
compared males;
newly diagnosed ... See more keywords
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Published in 2021 at "Clinical Epigenetics"
DOI: 10.1186/s13148-021-01044-2
Abstract: Background The promoter hypermethylation of the methylguanine-DNA methyltransferase gene is a frequently used biomarker in daily clinical practice as it is associated with a favorable prognosis in glioblastoma patients treated with temozolamide. Due to the…
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Keywords:
mgmt methylation;
methodology;
glioblastoma patients;
glioblastoma ... See more keywords
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Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e15770
Abstract: e15770 Background: Metastatic pancreatic cancer (mPAC) has a poor prognosis, with few therapeutic options and an overall survival (OS) at 5 years < 5%. O6-methylguanine-DNA methyltransferase ( MGMT) is a key DNA repair gene, responsible…
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Keywords:
dna repair;
mgmt;
cancer;
methylation ... See more keywords
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Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.2539
Abstract: 2539Background: MGMT methylation (MGMTmet) status represents an important prognostic factor for glioblastoma (GBM) patients (PTS). Quantitative pyrosequencing approach has proven to be feasible for...
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Keywords:
methylation;
glioblastoma;
prognostic role;
defining prognostic ... See more keywords
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Published in 2023 at "Cancers"
DOI: 10.3390/cancers15051384
Abstract: Simple Summary MGMT-methylated glioblastomas have significantly lower ADC values, as compared to the glioblastomas with no MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions…
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Keywords:
methylation status;
methylation;
mgmt methylation;
adc values ... See more keywords
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Published in 2021 at "Oncology Research"
DOI: 10.3727/096504021x16214197880808
Abstract: Unresectable neuroendocrine neoplasms (NENs) often poorly respond to standard therapeutic approaches. Alkylating agents, in particular temozolomide, commonly used to treat high-grade brain tumors including glioblastomas, have recently been tested in advanced or metastatic NENs, where…
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Keywords:
neuroendocrine neoplasms;
methylation;
evaluation mgmt;
mgmt methylation ... See more keywords