Riluzole enhances the antitumor effects of temozolomide via suppression of MGMT expression in glioblastoma.
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DOI: 10.3171/2019.12.jns192682
Abstract: OBJECTIVE Glutamatergic signaling significantly promotes proliferation, migration, and invasion in glioblastoma (GBM). Riluzole, a metabotropic glutamate receptor 1 inhibitor, reportedly suppresses GBM growth. However, the effects of combining riluzole with the primary GBM chemotherapeutic agent,… read more here.
Keywords: riluzole; tmz riluzole; gbm; mgmt positive ... See more keywords