MGMT promoter methylation status as a prognostic factor for the outcome of gamma knife radiosurgery for recurrent glioblastoma
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DOI: 10.1007/s11060-017-2478-9
Abstract: We conducted this study to determine whether the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter was a prognostic marker for positive outcomes of gamma knife radiosurgery (GKS) for recurrent glioblastoma (GBM). We retrospectively examined… read more here.
Keywords: methylation; mgmt promoter; recurrent; methylation status ... See more keywords
Temporal stability of MGMT promoter methylation in glioblastoma patients undergoing STUPP protocol
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DOI: 10.1007/s11060-017-2722-3
Abstract: Epigenetic silencing of O-6-methylguanine-DNA methyltransferase (MGMT) promoter via methylation in a glioblastoma (GBM), has been correlated with a more favourable response to alkylating chemotherapeutic agents such as temozolomide. The use of global methylation surrogates such… read more here.
Keywords: status; methylation; mgmt promoter; methylation status ... See more keywords
MGMT promoter methylation is not correlated with integrin expression in malignant gliomas: clarifying recent clinical trial results
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DOI: 10.1007/s12032-018-1162-z
Abstract: Integrin alpha-v-beta-3 (αvβ3) is important for invasive tumor growth and angiogenesis in glioblastomas (GBM). However, recent clinical trials on inhibition of this integrin led to ambiguous results whether patients with methylated or unmethylated 6O-methylguanine methyltransferase… read more here.
Keywords: integrin expression; mgmt promoter; expression;
The utilization of MGMT promoter methylation testing in United States hospitals for glioblastoma and its impact on prognosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2018.02.009
Abstract: Multiple studies have identified O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status to be an important prognostic factor in glioblastoma (GBM). We used the National Cancer Data Base (NCDB) to analyze completeness of coding for MGMT as… read more here.
Keywords: status; mgmt; mgmt promoter; promoter methylation ... See more keywords
Machine learning-based radiomic, clinical and semantic feature analysis for predicting overall survival and MGMT promoter methylation status in patients with glioblastoma.
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DOI: 10.1016/j.mri.2020.09.017
Abstract: INTRODUCTION Survival varies in patients with glioblastoma due to intratumoral heterogeneity and radiomics/imaging biomarkers have potential to demonstrate heterogeneity. The objective was to combine radiomic, semantic and clinical features to improve prediction of overall survival… read more here.
Keywords: status; patients glioblastoma; mgmt promoter; mgmt ... See more keywords
Perfusion parameters derived from MRI for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas.
Sign Up to like & getrecommendations! Published in 2021 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2021.09.005
Abstract: PURPOSE To investigate the feasibility for preoperative prediction of IDH mutation and MGMT promoter methylation status in glioblastomas(GBMs) by intravoxel incoherent motion(IVIM) and dynamic susceptibility contrast(DSC). METHODS Preoperative IVIM and DSC images of 71 patients(IDH… read more here.
Keywords: idh mutation; mgmt promoter; promoter methylation; mutation ... See more keywords
The Association Between MGMT Promoter Methylation and Patients with Gastric Cancer: A Meta-Analysis.
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DOI: 10.1089/gtmb.2016.0284
Abstract: AIMS Several previous studies have suggested that MGMT promoter methylation is significantly associated with gastric cancer, but the results were not consistent. Hence, we conducted a systematic meta-analysis to explore the potential correlation of MGMT… read more here.
Keywords: gastric cancer; promoter methylation; mgmt promoter;
Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter-methylated malignant astrocytoma.
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa033
Abstract: BACKGROUND O6-methylguanine DNA-methyl transferase (MGMT) promoter methylation status is predictive for alkylating chemotherapy, but there are non-benefitting subgroups. METHODS This is the long-term update of NOA-08 (NCT01502241) that compared efficacy and safety of radiotherapy (RT,… read more here.
Keywords: methylation; mgmt promoter; radiotherapy; promoter methylated ... See more keywords
NIMG-38. NON-INVASIVE PREDICTION OF MGMT PROMOTER METHYLATION USING COMBINED FET PET/MRI RADIOMICS
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DOI: 10.1093/neuonc/noaa215.651
Abstract: Recently, the Response Assessment in Neuro-Oncology (RANO) Working Group emphasized the additional diagnostic value of amino acid PET in addition to MRI. However, the number of studies using amino acid PET/MRI radiomics is still low.… read more here.
Keywords: promoter methylation; pet mri; mgmt promoter; fet pet ... See more keywords
Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial
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DOI: 10.1093/neuonc/noac099
Abstract: Abstract Background Addition of temozolomide (TMZ) to radiotherapy (RT) improves overall survival (OS) in patients with glioblastoma (GBM), but previous studies suggest that patients with tumors harboring an unmethylated MGMT promoter derive minimal benefit. The… read more here.
Keywords: unmethylated mgmt; phase iii; newly diagnosed; mgmt promoter ... See more keywords
A Comparison of Three Different Deep Learning-Based Models to Predict the MGMT Promoter Methylation Status in Glioblastoma Using Brain MRI
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DOI: 10.1093/neuonc/noac209.673
Abstract: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The standard treatment for GBM consists of surgical resection followed by concurrent chemoradiotherapy and adjuvant temozolomide. O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is… read more here.
Keywords: promoter methylation; brain; mgmt promoter; methylation status ... See more keywords