E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20143
Abstract: Altered processing of the Amyloid Precursor Protein (APP) is a well-recognized central pathogenic mechanism in Alzheimer's Disease (AD), and regulation of APP processing is a major focus of research in the AD field. However, how… read more here.
Keywords: processing; precursor protein; amyloid precursor; processing app ... See more keywords
Promoter Methylation of the MGRN1 Gene Predicts Prognosis and Response to Chemotherapy of High-Grade Serous Ovarian Cancer Patients
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.659254
Abstract: Aberrant DNA methylation is considered to play a critical role in the chemoresistance of epithelial ovarian cancer (EOC). In this study, we explored the relationship between hypermethylation of the Mahogunin Ring Finger 1 (MGRN1) gene… read more here.
Keywords: methylation; expression; ovarian cancer; hgsoc patients ... See more keywords
Distribution and Localization of Mahogunin Ring Finger 1 in the Mouse Central Nervous System
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DOI: 10.3390/ijms23168956
Abstract: Mahogunin ring finger 1 (MGRN1), an E3 ubiquitin, is involved in several physiological and neuropathological processes. Although mgrn1 mRNA is widely distributed in the central nervous system (CNS), detailed information on its cellular and subcellular… read more here.
Keywords: ring finger; central nervous; mahogunin ring; mgrn1 ... See more keywords