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   Articles with "mgx" as a keyword



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Dysfunction of SERCA pumps as novel mechanism of methylglyoxal cytotoxicity.

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recommendations! Published in 2018 at "Cell calcium"

DOI: 10.1016/j.ceca.2018.06.003

Abstract: A novel pathway of methylglyoxal (MGX)-induced apoptosis via sarcoplasmic reticulum Ca2+-ATPase (SERCA) is presented. Interaction of SERCA1 with MGX was investigated by molecular docking and experimentally in a cell-free system. MGX concentration- and time-dependently decreased… read more here.

Keywords: mgx; methylglyoxal; decrease; dysfunction serca ... See more keywords
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Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix (APX001A) in Candida Species

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recommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.01387-19

Abstract: Manogepix (MGX) targets the conserved fungal Gwt1 enzyme required for acylation of inositol early in the glycosylphosphatidylinositol biosynthesis pathway. The prodrug fosmanogepix is currently in clinical development for the treatment of invasive fungal infections. ABSTRACT… read more here.

Keywords: reduced susceptibility; gwt1; development; resistance ... See more keywords
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Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0270268

Abstract: Purpose To compare the safety and efficacy of intense pulsed light (IPL) followed by meibomian gland expression (MGX), against monotherapy of MGX. Methods Patients with moderate to severe meibomian gland dysfunction (MGD) were 1:1 randomized… read more here.

Keywords: disease; meibomian gland; gland; gland dysfunction ... See more keywords
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Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

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recommendations! Published in 2022 at "Journal of Fungi"

DOI: 10.3390/jof8101102

Abstract: Invasive fungal infections have mortality rates of 30–90%, depending on patient co-morbidities and the causative pathogen. The frequent emergence of drug resistance reduces the efficacy of currently approved treatment options, highlighting an urgent need for… read more here.

Keywords: fungal pathogens; gpi anchor; mgx; human fungal ... See more keywords