Tumor-Associated Macrophage-Derived Exosomal LINC01232 Induces the Immune Escape in Glioma by Decreasing Surface MHC-I Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207067
Abstract: Tumor-associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape. Mechanistically, LINC01232 is found to directly bind E2F2… read more here.
Keywords: mhc; surface; expression; escape ... See more keywords
Anatomical and molecular analyses of the deltoid muscle in chimpanzees (Pan troglodytes) and modern humans (Homo sapiens): Similarities and differences due to the uses of the upper extremity
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Primatology"
DOI: 10.1002/ajp.23390
Abstract: In the deltoid muscles of Pan troglodytes and Homo sapiens, we have analyzed the muscle architecture and the expression of the myosin heavy chain (MHC) isoforms. Our aim was to identify differences between the two… read more here.
Keywords: deltoid muscle; pan troglodytes; mhc; uses upper ... See more keywords
Relationship between genome‐wide and MHC class I and II genetic diversity and complementarity in a nonhuman primate
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DOI: 10.1002/ece3.9346
Abstract: Abstract Although mate choice is expected to favor partners with advantageous genetic properties, the relative importance of genome‐wide characteristics, such as overall heterozygosity or kinship, versus specific loci, is unknown. To disentangle genome‐wide and locus‐specific… read more here.
Keywords: mhc; genome wide; class; diversity ... See more keywords
TCR‐induced alteration of primary MHC peptide anchor residue
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DOI: 10.1002/eji.201948085
Abstract: The HLA‐A*02:01‐restricted decapeptide EAAGIGILTV, derived from melanoma antigen recognized by T‐cells‐1 (MART‐1) protein, represents one of the best‐studied tumor associated T‐cell epitopes, but clinical results targeting this peptide have been disappointing. This limitation may reflect… read more here.
Keywords: peptide; tcr induced; antigen; induced alteration ... See more keywords
A universal anti‐cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31795
Abstract: For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through… read more here.
Keywords: melanoma; invariant chain; mhc; cancer ... See more keywords
MHC Molecules, T cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins-Key Elements of Adaptive and Innate Immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_2
Abstract: Molecules encoded by the Major Histocompatibility Complex (MHC) bind self or foreign peptides and display these at the cell surface for recognition by receptors on T lymphocytes (designated T cell receptors-TCR) or on natural killer… read more here.
Keywords: mhc molecules; natural killer; cell receptors; mhc ... See more keywords
Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1057-3
Abstract: Baboons are valuable models for complex human diseases due to their genetic and physiologic similarities to humans. Deep sequencing methods to characterize full-length major histocompatibility complex (MHC) class I (MHC-I) alleles in different nonhuman primate… read more here.
Keywords: olive yellow; olive hybrid; primate; hybrid olive ... See more keywords
Divergence between genes but limited allelic polymorphism in two MHC class II A genes in Leach’s storm-petrels Oceanodroma leucorhoa
Sign Up to like & getrecommendations! Published in 2019 at "Immunogenetics"
DOI: 10.1007/s00251-019-01130-z
Abstract: The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of… read more here.
Keywords: leach storm; class; mhc; polymorphism ... See more keywords
An Illumina approach to MHC typing of Atlantic salmon
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DOI: 10.1007/s00251-019-01143-8
Abstract: The IPD-MHC Database represents the official repository for non-human major histocompatibility complex (MHC) sequences, overseen and supported by the Comparative MHC Nomenclature Committee, providing access to curated MHC data and associated analysis tools. IPD-MHC gathers… read more here.
Keywords: class; illumina approach; atlantic salmon; mhc ... See more keywords
Development and optimization of a hybridization technique to type the classical class I and class II B genes of the chicken MHC
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DOI: 10.1007/s00251-019-01149-2
Abstract: The classical class I and class II molecules of the major histocompatibility complex (MHC) play crucial roles in immune responses to infectious pathogens and vaccines as well as being important for autoimmunity, allergy, cancer and… read more here.
Keywords: classical class; class; hybridization; mhc ... See more keywords
IConMHC: a deep learning convolutional neural network model to predict peptide and MHC-I binding affinity
Sign Up to like & getrecommendations! Published in 2020 at "Immunogenetics"
DOI: 10.1007/s00251-020-01163-9
Abstract: Tumor-specific neoantigens are mutated self-peptides presented by tumor cell major histocompatibility complex (MHC) molecules and are necessary to elicit host’s anti-cancer cytotoxic T cell responses. It could be specifically recognized by neoantigen-specific T cell receptors… read more here.
Keywords: peptide mhc; model; mhc binding; mhc ... See more keywords