Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1915562116
Abstract: Significance The human population contains thousands of MHC-I alleles, showing a range of dependencies on molecular chaperones for loading of their peptide cargo, which are then displayed on the cell surface for T cell surveillance.… read more here.
Keywords: molecular determinants; mhc molecules; determinants chaperone; mhc alleles ... See more keywords
Depletion of MHC supertype during domestication can compromise immunocompetence
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DOI: 10.1111/mec.15763
Abstract: The major histocompatibility complex (MHC) plays an important role in infectious disease resistance. The presence of certain MHC alleles and functionally similar groups of MHC alleles (i.e., supertypes) has been associated with resistance to particular… read more here.
Keywords: mhc alleles; resistance; mhc; depletion mhc ... See more keywords
Immunogenetic variation shapes the gut microbiome in a natural vertebrate population
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DOI: 10.1186/s40168-022-01233-y
Abstract: Background The gut microbiome (GM) can influence many biological processes in the host, impacting its health and survival, but the GM can also be influenced by the host’s traits. In vertebrates, Major Histocompatibility Complex (MHC)… read more here.
Keywords: diversity; mhc alleles; mhc; ase ... See more keywords