Evidence for an involvement of the ubiquitin‐like modifier ISG15 in MHC class I antigen presentation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048646
Abstract: The IFN stimulated gene 15 (ISG15) encodes a 15‐kDa ubiquitin‐like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an… read more here.
Keywords: presentation; ubiquitin like; isg15; antigen presentation ... See more keywords
MHC class II-deficient mice allow functional human CD4+ T cell development.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250313
Abstract: Humanized mouse models have been developed to study cell-mediated immune responses to human pathogens in vivo. How immunocompetent human T cells are selected in a murine thymus in such humanized mice remains poorly explored. To… read more here.
Keywords: cell; mhc class; cd4; mice ... See more keywords
MHC class I diversity in chimpanzees and bonobos
Sign Up to like & getrecommendations! Published in 2017 at "Immunogenetics"
DOI: 10.1007/s00251-017-0990-x
Abstract: Major histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces of past or ongoing selective processes. The… read more here.
Keywords: class diversity; diversity chimpanzees; class; central chimpanzees ... See more keywords
A personal retrospective on the mechanisms of antigen processing
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-01098-2
Abstract: My intention here is to describe the history of the molecular aspects of the antigen processing field from a personal perspective, beginning with the early identification of the species that we now know as MHC… read more here.
Keywords: antigen processing; class; personal retrospective; retrospective mechanisms ... See more keywords
MHC class I diversity of olive baboons (Papio anubis) unravelled by next-generation sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1053-7
Abstract: The olive baboon represents an important model system to study various aspects of human biology and health, including the origin and diversity of the major histocompatibility complex. After screening of a group of related animals… read more here.
Keywords: diversity; class; next generation; generation sequencing ... See more keywords
Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1057-3
Abstract: Baboons are valuable models for complex human diseases due to their genetic and physiologic similarities to humans. Deep sequencing methods to characterize full-length major histocompatibility complex (MHC) class I (MHC-I) alleles in different nonhuman primate… read more here.
Keywords: olive yellow; olive hybrid; primate; hybrid olive ... See more keywords
Development and evaluation of a rapid and cost-efficient NGS-based MHC class I genotyping method for macaques by using a prevalent short-read sequencer.
Sign Up to like & getrecommendations! Published in 2021 at "Immunogenetics"
DOI: 10.1007/s00251-020-01199-x
Abstract: Rhesus macaque is one of the most widely used primate model animals for immunological research of infectious diseases including human immunodeficiency virus (HIV) infection. It is well known that major histocompatibility complex (MHC) class I… read more here.
Keywords: short read; method; ngs based; genotyping method ... See more keywords
A genetic variant in the placenta-derived MHC class I chain-related gene A increases the risk of preterm birth in a Chinese population
Sign Up to like & getrecommendations! Published in 2017 at "Human Genetics"
DOI: 10.1007/s00439-017-1834-3
Abstract: Preterm birth (PTB) is a predominant contributor to neonatal mortality and morbidity worldwide. However, the pathophysiology of PTB is not well-understood. We tested the hypothesis that single-nucleotide polymorphisms (SNPs) in the placenta-derived MHC class I… read more here.
Keywords: ptb; class chain; preterm birth; derived mhc ... See more keywords
Genetic variation and selection of MHC class I loci differ in two congeneric frogs
Sign Up to like & getrecommendations! Published in 2018 at "Genetica"
DOI: 10.1007/s10709-018-0016-0
Abstract: Major histocompatibility complex (MHC) genes encode proteins in the acquired immune response pathway that often show distinctive selection-driven patterns in wild vertebrate populations. We examined genetic variation and signatures of selection in the MHC class… read more here.
Keywords: selection mhc; genetic variation; mhc class; selection ... See more keywords
Genetic diversity and evolution of the MHC class II DRB gene in the Japanese marten, Martes melampus (Carnivora: Mustelidae)
Sign Up to like & getrecommendations! Published in 2020 at "Mammal Research"
DOI: 10.1007/s13364-020-00506-x
Abstract: High polymorphism in major histocompatibility complex (MHC) genes plays an essential role in the adaptive immune system of vertebrates for defense against various pathogens. To further understand the evolution of MHC in wildlife, partial sequences… read more here.
Keywords: evolution; evolution mhc; class drb; mhc ... See more keywords
Uncovering the underlying physical mechanism for cancer-immunity of MHC class I diversity.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.170
Abstract: The cancer cells are heterogeneous populated, which can be classified as MHC class I positive and MHC I class negative. They influence the immune system differently. In this work, we build a core cancer-immune circuit… read more here.
Keywords: topography; class diversity; cancer; mechanism cancer ... See more keywords