Inhibition of DYRK1a Enhances Cardiomyocyte Cycling After Myocardial Infarction
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DOI: 10.1161/circresaha.121.320005
Abstract: Background: DYRK1a (dual-specificity tyrosine phosphorylation-regulated kinase 1a) contributes to the control of cycling cells, including cardiomyocytes. However, the effects of inhibition of DYRK1a on cardiac function and cycling cardiomyocytes after myocardial infarction (MI) remain unknown.… read more here.
Keywords: inhibition dyrk1a; dyrk1a; cre fucci2ar; mhc cre ... See more keywords
Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis
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DOI: 10.3390/ijms24043094
Abstract: Transgenic expression of Cre recombinase driven by a specific promoter is normally used to conditionally knockout a gene in a tissue- or cell-type-specific manner. In αMHC-Cre transgenic mouse model, expression of Cre recombinase is controlled… read more here.
Keywords: cre; expression cre; mhc cre; expression ... See more keywords
Ablation of CXCR4 expression in cardiomyocytes exacerbates isoproterenol-induced cell death and heart failure
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DOI: 10.3892/ijmm.2022.5216
Abstract: CXCR4 is a seven-transmembrane-spanning Gi-coupled receptor for the SDF-1 chemokine and plays a critical role in cardiovascular development and post-injury repair. However, the specific role of CXCR4 in cardiomyocytes is incompletely understood. It was hypothesized… read more here.
Keywords: cxcr4 expression; ablation cxcr4; mhc cre; cxcr4 ... See more keywords