Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64408-3
Abstract: Radiation therapy has been shown to enhance the efficacy of various T cell-targeted immunotherapies that improve antigen-specific T cell expansion, T regulatory cell depletion, or effector T cell function. Additionally, radiation therapy has been proposed… read more here.
Keywords: cell; cancer cells; mhc expression; radiation ... See more keywords
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1760705
Abstract: ABSTRACT Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy remains restricted to a small percentage of patients. Several lines… read more here.
Keywords: chemotherapy; neoadjuvant chemotherapy; expression; mhc expression ... See more keywords
Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543013.84163.3a
Abstract: Allogeneic stem cell transplantation (SCT) is the preferred therapy for the majority of haematological malignancies, but its use is limited by graftversus-host disease (GVHD), the primary life threatening complication associated with this procedure. Donor T… read more here.
Keywords: march8; expression; host; cell ... See more keywords
Mechanism of effective combination radio-immunotherapy against 9464D-GD2, an immunologically cold murine neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004834
Abstract: Background Most pediatric cancers are considered immunologically cold with relatively few responding to immune checkpoint inhibition. We recently described an effective combination radio-immunotherapy treatment regimen (combination adaptive-innate immunotherapy regimen (CAIR)) targeting adaptive and innate immunity… read more here.
Keywords: immunologically cold; mhc expression; immunotherapy; gd2 ... See more keywords
Biological Consequences of MHC-II Expression by Tumor Cells in Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-3200
Abstract: Immunotherapy has emerged as a key pillar of cancer treatment. To build upon the recent successes of immunotherapy, intense research efforts are aimed at a molecular understanding of antitumor immune responses, identification of biomarkers of… read more here.
Keywords: tumor; tumor cells; biological consequences; cancer ... See more keywords
Abstract 2999: Hippo signaling pathway regulates cancer-cell-intrinsic MHC-II expression in melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2999
Abstract: MHC-II is known to be mainly expressed on the surface of antigen-presenting cells (APCs). Nevertheless, increasing evidence suggests that MHC-II is also expressed by solid tumor cancer cells and may be associated with better immunotherapy… read more here.
Keywords: mhc; mhc expression; melanoma; cancer cell ... See more keywords
Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-0812
Abstract: Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based genome-wide CRISPR screens with a data-mining approach to identify drugs that can upregulate MHC-I… read more here.
Keywords: expression; checkpoint blockade; immune checkpoint; mhc expression ... See more keywords
Hippo signaling pathway regulates cancer cell-intrinsic MHC-II expression.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0227
Abstract: MHC-II is known to be mainly expressed on the surface of antigen-presenting cells. Evidence suggests MHC-II is also expressed by cancer cells and may be associated with better immunotherapy responses. However, the role and regulation… read more here.
Keywords: mhc; mhc expression; cell intrinsic; cancer cell ... See more keywords
NL-201 upregulates MHC-I expression and intratumoral TCR diversity, and demonstrates robust antitumor activity as monotherapy and in combination with PD-1 blockade.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0304
Abstract: Cytokine engineering has shown promise as a means to create novel immunomodulatory agents or to improve upon the therapeutic potential of natural cytokines. NL-201, a de novo, hyperstable, interleukin-2 receptor alpha (IL-2Rα)-independent agonist of the… read more here.
Keywords: antitumor activity; monotherapy; activity; mhc expression ... See more keywords
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.882277
Abstract: Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory signals and IBD drugs can regulate their… read more here.
Keywords: tnf poly; mhc; mhc expression; poly dependent ... See more keywords
NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087206
Abstract: Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. MHC-I defects strongly correlate to defective expression of NLRC5, the transcriptional activator of MHC-I and antigen… read more here.
Keywords: mhc; mhc expression; ciita fusion; expression ... See more keywords