MHC Molecules, T cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins-Key Elements of Adaptive and Innate Immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9367-9_2
Abstract: Molecules encoded by the Major Histocompatibility Complex (MHC) bind self or foreign peptides and display these at the cell surface for recognition by receptors on T lymphocytes (designated T cell receptors-TCR) or on natural killer… read more here.
Keywords: mhc molecules; natural killer; cell receptors; mhc ... See more keywords
Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1915562116
Abstract: Significance The human population contains thousands of MHC-I alleles, showing a range of dependencies on molecular chaperones for loading of their peptide cargo, which are then displayed on the cell surface for T cell surveillance.… read more here.
Keywords: molecular determinants; mhc molecules; determinants chaperone; mhc alleles ... See more keywords
The new W family reconstructs the evolution of MHC genes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122079119
Abstract: The importance of adaptive immunity has been highlighted by the protection afforded by vaccination in the face of the current coronavirus pandemic. Much has been learned about the origins and subsequent evolution of the antigen-specific… read more here.
Keywords: mhc molecules; evolution mhc; class; class molecules ... See more keywords
Donor-derived exosomes: the trick behind the semidirect pathway of allorecognition
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000372
Abstract: Purpose of review The passenger leukocyte hypothesis predicts that after transplantation, donor antigen-presenting cells (APCs) from the graft present donor MHC molecules to directly alloreactive T cells in lymphoid organs. However, in certain transplantation models,… read more here.
Keywords: semidirect pathway; mhc molecules; donor mhc; donor ... See more keywords
Coronavirus Porcine Deltacoronavirus Upregulates MHC Class I Expression through RIG-I/IRF1-Mediated NLRC5 Induction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00158-22
Abstract: MHC-I molecules play a crucial role in antiviral immunity by presenting intracellular antigens to CD8+T lymphocytes and eliminating virus-infected cells by natural killer cells’ “missing-self recognition.” However, the manipulation of MHC molecules by coronaviruses remains… read more here.
Keywords: mhc molecules; mhc; porcine mhc; sla molecules ... See more keywords
Two Functional Variants of AP-1 Complexes Composed of either γ2 or γ1 Subunits Are Independently Required for Major Histocompatibility Complex Class I Downregulation by HIV-1 Nef
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.02039-19
Abstract: HIV-1 Nef mediates evasion of the host immune system by inhibiting MHC-I surface presentation of viral antigens. To achieve this goal, Nef modifies the intracellular trafficking of MHC-I molecules in several ways. Despite being the… read more here.
Keywords: hla; mhc; nef mediated; downregulation ... See more keywords
Combining Sequence Similarity with Physicochemical Properties to Predict Binders for MHC-II Molecules.
Sign Up to like & getrecommendations! Published in 2023 at "Studies in health technology and informatics"
DOI: 10.3233/shti230348
Abstract: Prediction of binders of the major histocompatibility complex class II (MHC-II) molecules is critical for T cell immunogenicity. As protein-protein interaction also relies on physicochemical properties, we aim to build a novel model combining sequence… read more here.
Keywords: mhc molecules; similarity physicochemical; combining sequence; physicochemical properties ... See more keywords
Chaperones and Catalysts: How Antigen Presentation Pathways Cope With Biological Necessity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.859782
Abstract: Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent on the identification of cell surface MHC molecules bearing peptides generated from either endogenous (MHC I) or exogenous (MHC II)… read more here.
Keywords: mhc molecules; antigen presentation; catalysts antigen; peptide loading ... See more keywords
New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.886672
Abstract: The functions of a wide variety of molecules with structures similar to the classical class I and class II molecules encoded by the major histocompatibility complex (MHC) have been studied by biochemical and structural studies… read more here.
Keywords: mhc molecules; mhc; class molecules; present peptides ... See more keywords