l- to d-Amino Acid Substitution in the Immunodominant LCMV-Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics
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DOI: 10.1021/acsomega.1c06964
Abstract: Presentation of pathogen-derived epitopes by major histocompatibility complex I (MHC-I) can lead to the activation and expansion of specific CD8+ T cell clones, eventually resulting in the destruction of infected target cells. Altered peptide ligands… read more here.
Keywords: mhc peptide; lcmv derived; substitution; gp33 ... See more keywords
Continuous Acquisition of MHC:Peptide Complexes by Recipient Cells Contributes to the Generation of Anti‐Graft CD8+ T Cell Immunity
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DOI: 10.1111/ajt.13996
Abstract: Understanding the evolution of the direct and indirect pathways of allorecognition following tissue transplantation is essential in the design of tolerance‐promoting protocols. On the basis that donor bone marrow–derived antigen‐presenting cells are eliminated within days… read more here.
Keywords: peptide complexes; transplantation; mhc; cell ... See more keywords
Hybrid gMLP model for interaction prediction of MHC-peptide and TCR
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DOI: 10.3389/fgene.2022.1092822
Abstract: Understanding the interaction of T-cell receptor (TCR) with major histocompatibility-peptide (MHC-peptide) complex is extremely important in human immunotherapy and vaccine development. However, due to the limited available data, the performance of existing models for predicting… read more here.
Keywords: interaction; tcr; gmlp model; peptide ... See more keywords