Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-22-1074
Abstract: Cancer-specific neoantigens created in the form of a covalent drug conjugated to a fragment of an intracellular oncoprotein selectively mark drug-resistant cancer cells for killing with bispecific T-cell engagers. read more here.
Keywords: inhibitors targeted; neoantigens covalent; covalent inhibitors; mhc restricted ... See more keywords
Immunodominant MHC-II Restricted Epitopes in Human Apolipoprotein B.
Sign Up to like & getrecommendations! Published in 2022 at "Circulation research"
DOI: 10.1161/circresaha.122.321116
Abstract: BACKGROUND CD (cluster of differentiation) 4+ T-cell responses to APOB (apolipoprotein B) are well characterized in atherosclerotic mice and detectable in humans. CD4+ T cells recognize antigenic peptides displayed on highly polymorphic HLA (human leukocyte… read more here.
Keywords: cd4 cells; cd4; artery disease; immunodominant mhc ... See more keywords