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   Articles with "mhcii" as a keyword



MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson’s HLA locus exhibits epigenetic regulation

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-95679-3

Abstract: Major histocompatibility complex class II (MHCII) molecules are antigen presentation proteins and increased in post-mortem Parkinson’s disease (PD) brain. Attempts to decrease MHCII expression have led to neuroprotection in PD mouse models. Our group reported… read more here.

Keywords: synuclein induced; mhcii reduction; mhcii; induced degeneration ... See more keywords

Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T Cell-Induced, and Infectious Colitis in Mice.

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recommendations! Published in 2020 at "Gastroenterology"

DOI: 10.1053/j.gastro.2020.06.049

Abstract: BACKGROUND & AIMS Intestinal epithelial cells (IECs) provide a barrier that separates the mucosal immune system from the luminal microbiota. IECs constitutively express low levels of major histocompatibility complex (MHC) class II proteins, which are… read more here.

Keywords: mhcii; cell induced; iec mice; colitis ... See more keywords

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells

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recommendations! Published in 2022 at "JCI Insight"

DOI: 10.1172/jci.insight.154250

Abstract: Acute graft versus host disease (aGvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT) inflicted by alloreactive T cells primed in secondary lymphoid organs (SLOs) and subsequent damage to aGvHD target tissues. In… read more here.

Keywords: cell; reticular cells; fibroblastic reticular; cd4 ... See more keywords

Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0206654

Abstract: Accurate predictions of T-cell epitopes would be useful for designing vaccines, immunotherapies for cancer and autoimmune diseases, and improved protein therapies. The humoral immune response involves uptake of antigens by antigen presenting cells (APCs), APC… read more here.

Keywords: mhcii; cell epitopes; cleavage; peptide mhcii ... See more keywords

MhcII Regulates Transmission of α-Synuclein-Seeded Pathology in Mice

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23158175

Abstract: MHCII molecules, expressed by professional antigen-presenting cells (APCs) such as T cells and B cells, are hypothesized to play a key role in the response of cellular immunity to α-synuclein (α-syn). However, the role of… read more here.

Keywords: transmission; pathology; pff; mice ... See more keywords