The First Step in Catalysis of the Radical S-Adenosylmethionine Methylthiotransferase MiaB Yields an Intermediate with a [3Fe-4S]0-like Auxiliary Cluster.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11093
Abstract: The enzyme MiaB catalyzes the attachment of a methylthio (-SCH3) group at the C2 position of N6-(isopentenyl)adenosine (i6A) in the final step of the biosynthesis of the hypermodified tRNA nucleotide 2-methythio-N6-(isopentenyl)adenosine (ms2i6A). MiaB belongs to… read more here.
Keywords: auxiliary cluster; miab; step; catalysis ... See more keywords
tRNA modification enzyme MiaB connects environmental cues to activation of Pseudomonas aeruginosa type III secretion system
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DOI: 10.1371/journal.ppat.1011027
Abstract: Pseudomonas aeruginosa, a major inhabitant of numerous environmental reservoirs, is a momentous opportunistic human pathogen associated with severe infections even death in the patients suffering from immune deficiencies or metabolic diseases. Type III secretion system… read more here.
Keywords: environmental cues; type iii; pseudomonas aeruginosa; miab ... See more keywords