MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23380
Abstract: Chemoresistance remains a major obstacle to the treatment of esophageal cancer (EC). Exosome-mediated transfer of long noncoding RNAs (lncRNAs) has recently been unveiled to correlate with the regulation of drug resistance in EC. This study… read more here.
Keywords: ec109 cells; ptx resistance; miat; resistance ... See more keywords
The lncRNA MIAT/miR-181a-5p axis regulates osteopontin (OPN)-mediated proliferation and apoptosis of human chondrocytes in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular histology"
DOI: 10.1007/s10735-022-10067-9
Abstract: Osteoarthritis (OA) is a slow-progressing degenerative joint disease mainly characterized by progressive cartilage loss and subchondral bone remodeling. Osteopontin (OPN) is a matrix extracellular glyco-phosphoprotein capable of regulating the expression levels of multiple factors linked… read more here.
Keywords: miat; apoptosis; axis; proliferation apoptosis ... See more keywords
Silence of lncRNA MIAT-mediated inhibition of DLG3 promoter methylation suppresses breast cancer progression via the Hippo signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109697
Abstract: As the foremost common female malignancy, breast cancer (BC) poses a significant public health stumbling block. Although treatment protocols have improved over the years, the overall prognosis of BC remains unsatisfactory. Extensive investigations have taken… read more here.
Keywords: methylation; dlg3; miat; hippo signaling ... See more keywords
LncRNA MIAT correlates with immune infiltrates and drug reactions in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107071
Abstract: Long non-coding RNA (lncRNA) is a kind of important molecules involved in the formation of immune landscape in tumor microenvironment. However, there are few studies on the relationship between lncRNA and immunomodulatory regulation of hepatocellular… read more here.
Keywords: immune; hepatocellular carcinoma; lncrna miat; miat ... See more keywords
LncRNA MIAT regulates autophagy and apoptosis of macrophage infected by Mycobacterium tuberculosis through the miR-665/ULK1 signaling axis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.07.023
Abstract: Accumulating lines of evidence have revealed the involvement of long non-coding RNAs (lncRNAs) in the control and elimination of invading Mycobacterium tuberculosis (Mtb) by macrophage. In this study, we sought to elucidate the role of… read more here.
Keywords: autophagy apoptosis; miat; mir 665; macrophage ... See more keywords
LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00538-y
Abstract: Dear Editor, Long non-coding RNA MIAT (lncR-MIAT) has recently been identified as a risk factor for myocardial infarction (MI). However, how lncR-MIAT controls MI remained yet to be determined. To shed light on this issue,… read more here.
Keywords: tspo; lncr miat; supplementary fig; miat ... See more keywords
lncRNA MIAT targets miR-411-5p/STAT3/PD-L1 axis mediating hepatocellular carcinoma immune response.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of experimental pathology"
DOI: 10.1111/iep.12440
Abstract: Emerging evidences have shown that long noncoding RNA (lncRNA) plays an important role in the immune escape of cancer cells. Our previous study has demonstrated that lncRNA MIAT is associated with the immune infiltration of… read more here.
Keywords: expression; hcc; miat; lncrna miat ... See more keywords
Upregulation of MIAT Regulates LOXL2 Expression by Competitively Binding MiR-29c in Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000491974
Abstract: Background/Aims: MIAT is a long noncoding RNA (lncRNA) involved in cell proliferation and the development of tumor. However, the exact effects and molecular mechanisms of MIAT in clear cell renal cell carcinoma (ccRCC) progression are… read more here.
Keywords: ccrcc; miat; expression; cell ... See more keywords
Abstract 211: Long Noncoding RNA Myocardial Infarction Associated Transcript, MIAT Exacerbates Maladaptive Cardiac Remodeling by Functioning as a Competing Endogenous RNA of MicroRNA-150 During Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.211
Abstract: Cardiac injury is accompanied by dynamic changes in the expression of noncoding RNAs such as microRNAs (miRs) and long noncoding RNAs (lncRNAs) that regulate target genes. We previously reported that β 1 -adrenergic receptor/β-arrestin1-responsive miR-150… read more here.
Keywords: long noncoding; miat; myocardial infarction; mir 150 ... See more keywords
Long non-coding RNA MIAT promotes growth and metastasis of colorectal cancer cells through regulation of miR-132/Derlin-1 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0477-8
Abstract: ObjectiveRecently, long non-coding RNA (lncRNA) MIAT has been demonstrated as an oncogenic gene in several types of cancer. However, the role and mechanism of MIAT in colorectal cancer (CRC) have not been investigated.MethodsReal-time PCR was… read more here.
Keywords: mir 132; miat; crc; cancer ... See more keywords
Long non-coding RNA MIAT promotes papillary thyroid cancer progression through upregulating LASP1
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-0913-z
Abstract: BackgroundAccumulating evidences indicate that long non-coding RNAs (lncRNAs) play an important role in initiation and development of thyroid cancer. However, the underlying molecular mechanism remains elusive.MethodsTo explore potential oncogenic and tumor suppressive lncRNAs in papillary… read more here.
Keywords: ptc; miat; thyroid cancer; lasp1 ... See more keywords