Targetable T-type Calcium Channels Drive Glioblastoma.
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DOI: 10.1158/0008-5472.can-16-2347
Abstract: Glioblastoma (GBM) stem-like cells (GSC) promote tumor initiation, progression, and therapeutic resistance. Here, we show how GSCs can be targeted by the FDA-approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2. This calcium channel… read more here.
Keywords: glioblastoma; type calcium; mibefradil; cav3 ... See more keywords