Current Consensus on I-131 MIBG Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s13139-018-0523-z
Abstract: Metaiodobenzylguanidine (MIBG) is structurally similar to the neurotransmitter norepinephrine and specifically targets neuroendocrine cells including some neuroendocrine tumors. Iodine-131 (I-131)-labeled MIBG (I-131 MIBG) therapy for neuroendocrine tumors has been performed for more than a quarter-century.… read more here.
Keywords: unresectable metastatic; 131 mibg; mibg therapy; mibg ... See more keywords
Association of plasma α-synuclein with cardiac 123I-MIBG scintigraphy in early Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136399
Abstract: Cardiac 123I-metaiodobenzylguanidine (MIBG) uptake correlates with the extent of cardiac sympathetic denervation found in disease with Lewy pathology, such as Parkinson's disease (PD). Protein α-synuclein, the main component of Lewy body, is a candidate biomarker… read more here.
Keywords: mibg; synuclein; parkinson disease; plasma synuclein ... See more keywords
Recent Advances in Radiopharmaceutical Theranostics of Pheochromocytoma and Paraganglioma.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2022.12.005
Abstract: As a rare kind of non-epithelial neuroendocrine neoplasms, paragangliomas (PGLs) exhibit various clinical characteristics with excessive catecholamine secretion and have been a research focus in recent years. Although several modalities are available nowadays, radiopharmaceuticals play… read more here.
Keywords: theranostics pheochromocytoma; pheochromocytoma paraganglioma; advances radiopharmaceutical; mibg ... See more keywords
P3559Renal sympathetic nerve activity, assessed by renal 123-iodine metaiodobenzylguanidine scintigraphy, reflects disease severity in heart failure with reduced ejection fraction
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz745.0422
Abstract: Sympathetic nerve activity is related to cardio-renal syndrome, which plays a crucial role in deterioration in heart failure with reduced ejection fraction (HFrEF). Previous studies reported that renal denervation was effective in HFrEF patients. Recently,… read more here.
Keywords: heart; heart failure; mibg; nerve activity ... See more keywords
The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes
Sign Up to like & getrecommendations! Published in 2017 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000000674
Abstract: Objective Molecular imaging of nigrostriatal dopamine transporters (DAT) and sympathetic cardiac innervation with single-photon emission computed tomography (SPECT) are useful tools for differentiating idiopathic Parkinson disease (PD) from other degenerative parkinsonian syndromes (non-PD). Nevertheless, these… read more here.
Keywords: combination; scintigraphy; spect; accuracy ... See more keywords
Functional Imaging Evidence of Tumor Response to High-Specific-Activity 131I-MIBG Therapy in an 84-Year-Old Patient With Metastatic Pheochromocytoma/Paraganglioma.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004519
Abstract: ABSTRACT An 84-year-old man with history of metastatic pheochromocytoma/paraganglioma (mPPGL) received surgery 13 years ago, with recent biopsy-proven mPPGL in the T11. 123I-MIBG scan showed MIBG-avid liver and osseous. Given his medical condition and body… read more here.
Keywords: pheochromocytoma paraganglioma; metastatic pheochromocytoma; year old; patient ... See more keywords
Clinical Applications and the Roles of Transporters in Disposition, Tumor Targeting, and Tissue Toxicity of meta-Iodobenzylguanidine
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000707
Abstract: Transporters on the plasma membrane of tumor cells are promising molecular “Trojan horses” to deliver drugs and imaging agents into cancer cells. Radioiodine-labeled meta-iodobenzylguanidine (mIBG) is used as a diagnostic agent (123I-mIBG) and a targeted… read more here.
Keywords: disposition; meta iodobenzylguanidine; normal tissues; mibg ... See more keywords
Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy
Sign Up to like & getrecommendations! Published in 2017 at "Polish Journal of Radiology"
DOI: 10.12659/pjr.901853
Abstract: Summary Background Evaluation of a patient with melanoma in whom an adrenal mass was detected on CT and MR during follow-up and further characterized with PET-CT and MIBG scintigraphy. Case Report In this case report,… read more here.
Keywords: integrated imaging; scintigraphy; imaging characterization; adrenal adenoma ... See more keywords
MIBG Therapy for Neuroblastoma: Precision Achieved With Dosimetry, and Concern for False Responders
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.00173
Abstract: Neuroblastoma causes 15% of cancer mortality in children. High risk neuroblastoma has poor prognosis, with high relapse rate and mortality despite multimodal treatment. 123-I-meta-iodo-benzyl-guanidine (mIBG) scintigraphy is one of the current standard diagnostic procedures in… read more here.
Keywords: response; treatment; neuroblastoma; mibg ... See more keywords
Cardiac 123I-mIBG Imaging in Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060656
Abstract: Cardiac sympathetic upregulation is one of the neurohormonal compensation mechanisms that play an important role in the pathogenesis of chronic heart failure (CHF). In the past decades, cardiac 123I-mIBG scintigraphy has been established as a… read more here.
Keywords: 123i mibg; heart failure; cardiac 123i; chf ... See more keywords
131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours - a single-centre study.
Sign Up to like & getrecommendations! Published in 2018 at "Endokrynologia Polska"
DOI: 10.5603/ep.a2018.0024
Abstract: INTRODUCTION Pheochromocytomas and paragangliomas are rare tumors deriving from chromaffin cells of adrenal medulla or paraganglia. They are usually benign but 10-35% of them present malignant behavior. The aim of the study was to evaluate… read more here.
Keywords: 131 mibg; mibg therapy; treatment; study ... See more keywords