Micafungin Population PK Analysis in Healthy and Septic Pigs: Can the Septic Porcine Model Predict the Micafungin PK in Septic Patients?
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DOI: 10.1007/s11095-021-03137-2
Abstract: OBJECTIVES To describe micafungin pharmacokinetic (PK) alterations of sepsis induced in piglets and to determine whether the porcine septic model is able to predict the PK of micafungin in septic patients at the plasma and… read more here.
Keywords: micafungin septic; porcine; micafungin; septic patients ... See more keywords
Antifungal drug susceptibility, molecular basis of resistance to echinocandins and molecular epidemiology of fluconazole resistance among clinical Candida glabrata isolates in Kuwait
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DOI: 10.1038/s41598-020-63240-z
Abstract: Candida glabrata readily develops resistance to echinocandins. Identification, antifungal susceptibility testing (AST) and resistance mechanism to echinocandins among C. glabrata was determined in Kuwait. C. glabrata isolates (n = 75) were tested by Vitek2, multiplex PCR and/or… read more here.
Keywords: micafungin; susceptibility; epidemiology; resistance ... See more keywords
Anti-Candida auris activity in vitro and in vivo of micafungin loaded nanoemulsions.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology"
DOI: 10.1093/mmy/myac090
Abstract: Fungi are becoming increasingly resistant, especially the new strains. Therefore, this work developed nanoemulsions (NE) containing micafungin (MICA), in order to improve its action against infections caused by Candida auris. The NEs were composed by… read more here.
Keywords: vitro vivo; vivo; candida auris; activity ... See more keywords
Low and constant micafungin concentrations may be sufficient to lead to resistance mutations in FKS2 gene of Candida glabrata.
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DOI: 10.1093/mmy/myx124
Abstract: We studied the ability of five echinocandin-susceptible C. glabrata isolates to acquire in vitro resistance to anidulafungin and micafungin. All isolates became phenotypically resistant after 2-4 days of exposure to low and constant micafungin concentrations… read more here.
Keywords: micafungin; micafungin concentrations; constant micafungin; low constant ... See more keywords
61. Evaluation of the Impact of a Micafungin Time-Out Protocol for Hospitalized Patients
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.106
Abstract: Echinocandin overuse is associated with increased prevalence of non-albicans Candida spp, resistance, and high costs. Prospective review of micafungin prescribing by an Antimicrobial Stewardship Pharmacist (ASP) has shown reduced rates of inappropriate therapy. The aim… read more here.
Keywords: micafungin; mto; micafungin time; post mto ... See more keywords
732. Evaulation of Micafungin Treatment at Pediatric Patients: A cross-sectional Study from Tertiary Pediatric Centre
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.924
Abstract: Micafungin is one of three currently available echinocandin for treatment of candidiasis and candidemia. Children who were treated for micafungin for possible or proven invasive Candidia infection between May 2017 and October 2019 were included.… read more here.
Keywords: micafungin; cross sectional; candida spp; micafungin treatment ... See more keywords
Use of Micafungin for the Prevention and Treatment of Invasive Fungal Infections in Everyday Pediatric Care in France: Results of the MYRIADE Study.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Infectious Disease Journal"
DOI: 10.1097/inf.0000000000002353
Abstract: BACKGROUND Invasive fungal infections are responsible for significant morbidity and mortality. Safety and effectiveness of antifungal agents is a particular concern in pediatric populations, where data are often limited. Micafungin is an echinocandin with demonstrated… read more here.
Keywords: micafungin; treatment; fungal infections; study ... See more keywords
Serine/Threonine Phosphatase Calcineurin Orchestrates the Intrinsic Resistance to Micafungin in the Human-Pathogenic Fungus Mucor circinelloides
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DOI: 10.1128/aac.00686-22
Abstract: Procedures such as solid-organ transplants and cancer treatments can leave many patients in an immunocompromised state. This leads to their increased susceptibility to opportunistic diseases such as fungal infections. ABSTRACT Procedures such as solid-organ transplants… read more here.
Keywords: fksa fksb; mucor circinelloides; calcineurin; intrinsic resistance ... See more keywords
Pharmacokinetic Properties of Micafungin in Critically Ill Patients Diagnosed with Invasive Candidiasis
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DOI: 10.1128/aac.01398-17
Abstract: ABSTRACT The estimated attributable mortality rate for invasive candidiasis (IC) in the intensive care unit (ICU) setting varies from 30 to 40%. Physiological changes in critically ill patients may affect the distribution and elimination of… read more here.
Keywords: micafungin; invasive candidiasis; ill patients; liter ... See more keywords
Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata
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DOI: 10.1128/aac.01692-18
Abstract: Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in Candida mutational frequency of resistance or propensity to develop FKS mutations. ABSTRACT Echinocandins are front-line agents for treatment of… read more here.
Keywords: micafungin; fks mutation; caspofungin; mutational frequency ... See more keywords
Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment
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DOI: 10.1177/1060028019892587
Abstract: Background: Micafungin is increasingly used in the treatment and prevention of candidiasis in hospitalized patients. Limited data are available from which to assess the risk of drug-induced liver injury (DILI) with micafungin. No studies, to… read more here.
Keywords: micafungin; dili micafungin; dili; causality assessment ... See more keywords