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   Articles with "mice" as a keyword



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Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels

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recommendations! Published in 2017 at "Febs Letters"

DOI: 10.1002/1873-3468.12651

Abstract: Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late‐stage AD. Here, we provide evidence that indicates that this decrease is associated with the AD‐linked angiopathy. While wild‐type mice of… read more here.

Keywords: rest nrsf; app23 mice; pathology; expression ... See more keywords

Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin‐deficient mice and Duchenne muscular dystrophy

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recommendations! Published in 2018 at "Febs Letters"

DOI: 10.1002/1873-3468.13099

Abstract: Duchenne muscular dystrophy (DMD) is a fatal disorder caused by absence of functional dystrophin protein. Compensation in dystrophin‐deficient (mdx) mice may be achieved by overexpression of its fetal paralogue, utrophin. Strategies to increase utrophin levels… read more here.

Keywords: mice; muscular dystrophy; dystrophin deficient; duchenne muscular ... See more keywords

A readout of metabolic efficiency in arylamine N‐acetyltransferase‐deficient mice reveals minor energy metabolism changes

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recommendations! Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13357

Abstract: Recent studies have revealed a possible link between the activities of polymorphic arylamine N‐acetyltransferases (NATs) and energy metabolism. We used a Nat1/Nat2 double knockout (KO) mouse model to demonstrate that ablation of the two Nat… read more here.

Keywords: energy; readout metabolic; mice; energy metabolism ... See more keywords
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Maintenance of liver glycogen during long‐term fasting preserves energy state in mice

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13770

Abstract: Glycogen shortage during fasting coincides with dramatic changes in hepatic adenine nucleotide levels. The aim of this work was to study the relevance of liver glycogen in the regulation of the hepatic energy state during… read more here.

Keywords: energy state; glycogen; mice; liver glycogen ... See more keywords

Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin‐knockout mice

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12587

Abstract: High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein‐coupled receptor APJ and has possible roles in energy… read more here.

Keywords: hypoxia; metabolism; hypoxia exposure; mice ... See more keywords

In‐depth multiomic characterization of the effects of obesity in high‐fat diet‐fed mice

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recommendations! Published in 2024 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13788

Abstract: High‐fat diet (HFD)‐fed mice have been widely used in the clinical investigation of obesity. However, the long‐term effect of HFD on gut microbiota and metabolites, plasma and liver metabolomics, colonic and liver transcriptomics remain largely… read more here.

Keywords: mice; fat diet; fed mice; metabolism ... See more keywords

Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice

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recommendations! Published in 2024 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13802

Abstract: The Ras homology (Rho) family of GTPases serves various functions, including promotion of cell migration, adhesion, and transcription, through activation of effector molecule targets. One such pair of effectors, the Rho‐associated coiled‐coil kinases (ROCK1 and… read more here.

Keywords: rock1 rock2; mice; cell; adult mice ... See more keywords

Auditory neuropathy in mice and humans with Friedreich ataxia.

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recommendations! Published in 2023 at "Annals of clinical and translational neurology"

DOI: 10.1002/acn3.51777

Abstract: OBJECTIVE Recent studies have found that human Friedreich ataxia patients have dysfunction of transmission in the auditory neural pathways. Here, we characterize hearing deficits in a mouse model of Friedreich ataxia and compare these to… read more here.

Keywords: steady state; friedreich ataxia; auditory steady; mice ... See more keywords

Endothelial Retargeting of AAV9 In Vivo

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202103867

Abstract: Adeno‐associated viruses (AAVs) are frequently used for gene transfer and gene editing in vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV‐transduction. AAVs are retargeted here toward endothelial cells by coating with… read more here.

Keywords: endothelial cells; endothelial retargeting; g2cnn aav9; mice ... See more keywords

Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202105120

Abstract: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Serine‐arginine rich splicing factor 3 (SRSF3) plays a critical role in hepatocyte function and its loss in mice promotes chronic liver damage and leads to… read more here.

Keywords: hepatocellular carcinoma; damage; hepatocyte; dna damage ... See more keywords

An Optogenetic‐Controlled Cell Reprogramming System for Driving Cell Fate and Light‐Responsive Chimeric Mice

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202202858

Abstract: Pluripotent stem cells (PSCs) hold great promise for cell‐based therapies, disease modeling, and drug discovery. Classic somatic cell reprogramming to generate induced pluripotent stem cells (iPSCs) is often achieved based on overexpression of transcription factors… read more here.

Keywords: system; cell; cell fate; mice ... See more keywords