An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys)
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DOI: 10.1126/sciadv.adf2331
Abstract: Although most mammals heal wounds with scar tissue, spiny mice (Acomys cahirinus) naturally regenerate skin and complex musculoskeletal tissues. The core signaling pathways driving mammalian tissue regeneration are poorly characterized. Here, we show that MAPK/ERK… read more here.
Keywords: regeneration; fibrosis; mice acomys; spiny mice ... See more keywords
Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis
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DOI: 10.1371/journal.pone.0241617
Abstract: The study of long-lived and regenerative animal models has revealed diverse protective responses to stressors such as aging and tissue injury. Spiny mice (Acomys) are a unique mammalian model of skin wound regeneration, but their… read more here.
Keywords: mice acomys; skin; skin epidermis; mice ... See more keywords
Spiny mice (Acomys) cells fail to engraft in NOD scid gamma
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DOI: 10.1371/journal.pone.0286000
Abstract: Immune cells and stromal cells regulate wound healing and regeneration through complex activation patterns with spatiotemporal variation. The scarless regeneration of Spiny mice (Acomys species) is no exception; differential activation of immune and stromal cell… read more here.
Keywords: nod scid; acomys cells; spiny mice; scid gamma ... See more keywords