Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations
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DOI: 10.1186/s13073-024-01394-5
Abstract: Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic contribution, and investigating the genes and regulatory interactions underlying hearing loss offers… read more here.
Keywords: mice carrying; loss; pathological mechanisms; mechanisms candidate ... See more keywords
Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes
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DOI: 10.2337/db17-1509
Abstract: Phosphatidylinositol 3-kinase (PI3K) plays a central role in insulin signaling, glucose metabolism, cell growth, cell development, and apoptosis. A heterozygous missense mutation (R649W) in the p85α regulatory subunit gene of PI3K (PIK3R1) has been identified… read more here.
Keywords: pi3k; mutation protected; mice carrying; obesity ... See more keywords