Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.06.033
Abstract: Accumulating evidence suggests that glutamatergic signaling and synaptic plasticity underlie one of a number of ways psychiatric disorders appear. The present study reveals a possible mechanism by which this occurs, through highlighting the importance of… read more here.
Keywords: psychiatric disease; glua1 trafficking; mice display; lmtk3 mice ... See more keywords
CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42681
Abstract: CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target. However the success… read more here.
Keywords: inflammatory; cxcr2 deficient; deficient mice; mice display ... See more keywords
Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.857820
Abstract: SLC6A20A is a proline and glycine transporter known to regulate glycine homeostasis and NMDA receptor (NMDAR) function in the brain. A previous study found increases in ambient glycine levels and NMDA receptor-mediated synaptic transmission in… read more here.
Keywords: homozygous mutant; heterozygous homozygous; slc6a20a heterozygous; mutant mice ... See more keywords
Adipose tissues of MPC1± mice display altered lipid metabolism-related enzyme expression levels
Sign Up to like & getrecommendations! Published in 2018 at "PeerJ"
DOI: 10.7717/peerj.5799
Abstract: Mitochondrial pyruvate carrier 1 (MPC1) is a component of the MPC1/MPC2 heterodimer that facilitates the transport of pyruvate into mitochondria. Pyruvate plays a central role in carbohydrate, fatty, and amino acid catabolism. The present study… read more here.
Keywords: mpc1 mice; metabolism; tissues mpc1; mice display ... See more keywords