Transgenic mice expressing human IL-32 develop adipokine profiles resembling those of obesity-induced metabolic changes.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154793
Abstract: Low-grade inflammation is associated with the development of insulin resistance in obese individuals. The present study aims to provide additional evidence strengthening the role of interleukin (IL)-32 in this key process. Using an IL-32 transgenic… read more here.
Keywords: expressing human; transgenic mice; insulin resistance; mice ... See more keywords
Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006214
Abstract: Key Points We generated novel hemophilia A or B mice expressing human protein C. Selectively blocking the anticoagulant activity of human activated protein C improves the clotting defects in hemophilia mice. read more here.
Keywords: human protein; mice expressing; expressing human; anticoagulant activity ... See more keywords
Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113554
Abstract: Granzyme A (gzmA), a serine protease involved in the modulation of the inflammatory immune response, is found at an elevated level in the serum from ALS patients. However, the influence of gzmA on the progression… read more here.
Keywords: mice expressing; hsod1g93a transgene; gzma; mice ... See more keywords
Choline Supplementation Does Not Promote Atherosclerosis in CETP-Expressing Male Apolipoprotein E Knockout Mice
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14081651
Abstract: Dietary trimethylamines, such as choline, metabolized by intestinal microbiota to trimethylamine are absorbed by the gut and oxidized to trimethylamine N-oxide (TMAO). The objective of this study was to determine the effect of choline supplementation… read more here.
Keywords: choline supplementation; promote atherosclerosis; choline; mice expressing ... See more keywords