Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria
Sign Up to like & getrecommendations! Published in 2021 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-021-02065-7
Abstract: We have previously shown that histamine (2-(1H-imidazol-4-yl)ethanamine) exerted concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic (H2R-TG) mice that overexpress the human H2 histamine… read more here.
Keywords: h2r mice; mice human; histamine; h2r ... See more keywords
HDAC6 inhibition and deletion reduce COPD symptoms in mice and human airway epithelia
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2020.5033
Abstract: The Histone Deacetylase 6 (HDAC6) enzyme has two deacetylase domains and is found almost exclusively in the cytoplasm. It deacetylates targets such as tubulin, cortactin, HSP90, KU70 and potentially the Treg-specific transcription factor FOXP3 but… read more here.
Keywords: hdac6 inhibition; mice human; epithelia; copd ... See more keywords