The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2274-0
Abstract: The metabolic fate of the human hepatotoxin fenclozic acid ([2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid) (Myalex) was studied in normal and bile-cannulated chimeric mice with a humanized liver, following oral administration of 10 mg/kg. This in vivo animal model was… read more here.
Keywords: mice humanized; chimeric mice; fenclozic acid; acid ... See more keywords
Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf2982
Abstract: The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ circadian… read more here.
Keywords: hepatocyte clocks; central pacemaker; physiology; humanized livers ... See more keywords
Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.565431
Abstract: Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and… read more here.
Keywords: humanized mice; cell polarization; mice humanized; der ... See more keywords
Mice with humanized immune system as novel models to study HIV-associated pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.936164
Abstract: People living with HIV and who receive antiretroviral therapy have a significantly improved lifespan, compared to the early days without therapy. Unfortunately, persisting viral replication in the lungs sustains chronic inflammation, which may cause pulmonary… read more here.
Keywords: pulmonary hypertension; hiv; humanized immune; study hiv ... See more keywords
Simultaneous measurement of mouse and human albumin in chimeric mice with humanized livers.
Sign Up to like & getrecommendations! Published in 2022 at "Bioanalysis"
DOI: 10.4155/bio-2021-0250
Abstract: Background: The degree of human hepatocyte replacement in chimeric mice with humanized liver has previously been shown to correlate with human plasma albumin measurements. However, there are no reports that directly compare the remaining endogenous mouse albumin with the newly… read more here.
Keywords: chimeric mice; mouse; human albumin; mice ... See more keywords