GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
Sign Up to like & getrecommendations! Published in 2019 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2018.12.016
Abstract: Summary GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological… read more here.
Keywords: nutritional stress; gdf15 provides; gdf15; stress ... See more keywords
Cisplatin is retained in the cochlea indefinitely following chemotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01837-1
Abstract: Cisplatin chemotherapy causes permanent hearing loss in 40–80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively… read more here.
Keywords: chemotherapy; cisplatin retained; cisplatin; cochlea ... See more keywords
Artificially produced gametes in mice, humans and other species
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction, Fertility and Development"
DOI: 10.1071/rd20265
Abstract: The production of gametes from pluripotent stem cells in culture, also known as in vitro gametogenesis, will make an important contribution to reproductive biology and regenerative medicine, both as a unique tool for understanding germ cell… read more here.
Keywords: pluripotent stem; mice humans; development; vitro gametogenesis ... See more keywords
Suppressive mechanisms of regulatory B cells in mice and humans
Sign Up to like & getrecommendations! Published in 2022 at "International Immunology"
DOI: 10.1093/intimm/dxac048
Abstract: Abstract B cells include immune-suppressive fractions, called regulatory B cells (Bregs), which regulate inflammation primarily through an interleukin 10 (IL-10)-mediated inhibitory mechanism. Several B-cell fractions have been reported as IL-10-producing Bregs in murine disease models… read more here.
Keywords: suppressive mechanisms; mechanisms regulatory; regulatory cells; cells mice ... See more keywords
Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Aging"
DOI: 10.1101/2022.02.23.481643
Abstract: Aging is associated with auditory nerve (AN) functional deficits and decreased inhibition in the central auditory system, amplifying central responses in a process known as central gain. Although central gain enhances response amplitudes, central gain… read more here.
Keywords: auditory; age related; mice humans; gain ... See more keywords
Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans
Sign Up to like & getrecommendations! Published in 2021 at "Hypertension"
DOI: 10.1161/hypertensionaha.120.16895
Abstract: Supplemental Digital Content is available in the text. Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream… read more here.
Keywords: stiffening; mice humans; blood pressure; aortic stiffening ... See more keywords
Neuropeptide Y expression marks partially differentiated β cells in mice and humans.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.94005
Abstract: β Cells are formed in embryonic life by differentiation of endocrine progenitors and expand by replication during neonatal life, followed by transition into functional maturity. In this study, we addressed the potential contribution of neuropeptide… read more here.
Keywords: npy expression; cells mice; neuropeptide expression; expression ... See more keywords
Translating Mouse Models
Sign Up to like & getrecommendations! Published in 2017 at "Toxicologic Pathology"
DOI: 10.1177/0192623316675767
Abstract: Mice and humans branched from a common ancestor approximately 80 million years ago. Despite this, mice are routinely utilized as animal models of human disease and in drug development because they are inexpensive, easy to… read more here.
Keywords: mouse models; translating mouse; pathology; mice humans ... See more keywords
EXPRESS: Two Variations and One Similarity in Memory Functions Deployed by Mice and Humans to Support Foraging.
Sign Up to like & getrecommendations! Published in 2021 at "Quarterly journal of experimental psychology"
DOI: 10.1177/17470218211010576
Abstract: Assessing variations in cognitive function between humans and animals is vital for understanding the idiosyncrasies of human cognition and for refining animal models of human brain function and disease. We determined memory functions deployed by… read more here.
Keywords: deployed mice; memory functions; mice humans; mice ... See more keywords
Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans[S]
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m093351
Abstract: Bis(monoacylglycerol)phosphate (BMP) is a phospholipid that is crucial for lipid degradation and sorting in acidic organelles. Genetic and drug-induced lysosomal storage disorders (LSDs) are associated with increased BMP concentrations in tissues and in the circulation.… read more here.
Keywords: mice humans; monoacylglycerol phosphate; bmp; bis monoacylglycerol ... See more keywords
γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010103
Abstract: Yersinia pseudotuberculosis is a foodborne pathogen that subverts immune function by translocation of Yersinia outer protein (Yop) effectors into host cells. As adaptive γδ T cells protect the intestinal mucosa from pathogen invasion, we assessed… read more here.
Keywords: yersinia pseudotuberculosis; mice humans; ifn production; pseudotuberculosis ... See more keywords