Mice lacking L‐12/15‐lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia Open"
DOI: 10.1002/epi4.12221
Abstract: Studies have addressed the potential involvement of L‐12/15‐lipoxygenases (LOs), a polyunsaturated fatty acid metabolizing enzyme, in experimental models of acute stroke and chronic neurodegeneration; however, none to our knowledge has explored its role in epilepsy… read more here.
Keywords: increased mortality; epileptogenesis; show increased; mice lacking ... See more keywords
Neuron‐specific cilia loss differentially alters locomotor responses to amphetamine in mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24755
Abstract: The neural mechanisms that underlie responses to drugs of abuse are complex, and impacted by a number of neuromodulatory peptides. Within the past 10 years it has been discovered that several of the receptors for… read more here.
Keywords: responses amphetamine; lacking cilia; cilia loss; mice lacking ... See more keywords
Affinity Purification of Neuropeptide Precursors from Mice Lacking Carboxypeptidase E Activity.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7537-2_13
Abstract: Peptidomic techniques are powerful tools to identify peptides in a biological sample. This protocol describes a targeted peptidomic approach that uses affinity chromatography to purify peptides that are substrates of carboxypeptidase E (CPE), an enzyme… read more here.
Keywords: affinity; cpe substrates; purification neuropeptide; affinity purification ... See more keywords
Hypomyelination and cognitive impairment in mice lacking CD133 (Prominin-1).
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.072
Abstract: The CD133 antigen, also known as prominin-1, is a glycoprotein that specifically localizes to plasma membrane protrusions. The precise function of CD133 remains unknown, but it is expressed in various progenitor cells including those derived… read more here.
Keywords: lacking cd133; hypomyelination; cd133; prominin ... See more keywords
Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.09.057
Abstract: INTRODUCTION Recent genome wide association studies (GWAS) identified a novel susceptibility locus for thrombosis, harbouring the SLC44A2 gene which encodes the Solute Carrier Family 44 Member 2 protein (SLC44A2). Thus far, SLC44A2 has not been… read more here.
Keywords: mice lacking; mice; slc44a2; gene ... See more keywords
Functional domains of the FgfrL1 receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.01.003
Abstract: FgfrL1 is a novel growth factor receptor that is primarily expressed in musculoskeletal tissues and the kidney. FgfrL1-deficient mice have a malformed diaphragm and no kidneys. Such animals die immediately after birth because they are… read more here.
Keywords: fgfrl1 receptor; domains fgfrl1; mice lacking; functional domains ... See more keywords
Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22617-y
Abstract: Endothelial cells play a key role in the regulation of disease. Defective regulation of endothelial cell homeostasis may cause mesenchymal activation of other endothelial cells or neighboring cell types, and in both cases contributes to… read more here.
Keywords: glucocorticoid receptor; mice lacking; endothelial cells; endothelial glucocorticoid ... See more keywords
Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53900-0
Abstract: Adamts16 encodes a disintegrin-like and metalloproteinase with thrombospondin motifs, 16, a member of a family of multi-domain, zinc-binding proteinases. ADAMTS-16 is implicated in a number of pathological conditions, including hypertension, cancer and osteoarthritis. A large… read more here.
Keywords: male mice; male; mice lacking; testis determination ... See more keywords
Mice lacking paternal expression of imprinted Grb10 are risk‐takers
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.1111/gbb.12679
Abstract: The imprinted genes Grb10 and Nesp influence impulsive behavior on a delay discounting task in an opposite manner. A recently developed theory suggests that this pattern of behavior may be representative of predicted effects of… read more here.
Keywords: risk; grb10; lacking paternal; risk taking ... See more keywords
Mice lacking global Stap1 expression do not manifest hypercholesterolemia
Sign Up to like & getrecommendations! Published in 2020 at "BMC Medical Genetics"
DOI: 10.1186/s12881-020-01176-x
Abstract: Background Autosomal dominant familial hypercholesterolemia (ADH; MIM#143890) is one of the most common monogenic disorders characterized by elevated circulatory LDL cholesterol. Initial studies in humans with ADH identified a potential relationship with variants of the… read more here.
Keywords: global stap1; hypercholesterolemia; lacking global; stap1 ... See more keywords
Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2017.00004
Abstract: The cholinergic system has extensive projections to the olfactory bulb (OB) where it produces a state-dependent regulation of sensory gating. Previous work has shown a prominent role of muscarinic acetylcholine (ACh) receptors (mAChRs) in regulating… read more here.
Keywords: lacking muscarinic; odor discrimination; mice lacking; muscarinic acetylcholine ... See more keywords