Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103328
Abstract: Summary A quarter of all seasonal influenza cases are caused by type B influenza virus (IBV) that also dominates periodically. Here, we investigated a recombinant adenovirus vaccine carrying a synthetic HA2 representing the consensus sequence… read more here.
Keywords: protection; genetic lineages; vaccine; mice lethal ... See more keywords
Intranasal vaccination with ebola virus GP amino acids 258-601 protects mice against lethal challenge.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.09.003
Abstract: Ebola virus (EBOV) disease (EVD) leads to lethal hemorrhagic fever with a case fatality rate as high as 90%, thus posing a serious global public health concern. However, while several vaccines based on the EBOV… read more here.
Keywords: ebola virus; challenge; mice lethal; vaccination ... See more keywords
Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge
Sign Up to like & getrecommendations! Published in 2018 at "NPJ Vaccines"
DOI: 10.1038/s41541-018-0063-7
Abstract: Seasonal vaccines are currently the most effective countermeasure against influenza. However, seasonal vaccines are only effective against strains closely related to the influenza strains contained in the vaccine. Recently a new hemagglutinin (HA) stem-based antigen,… read more here.
Keywords: mice lethal; mini; influenza; vaccine ... See more keywords
Estrogens Protect Calsequestrin-1 Knockout Mice from Lethal Hyperthermic Episodes by Reducing Oxidative Stress in Muscle
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DOI: 10.1155/2017/6936897
Abstract: Oxidative stress has been proposed to play a key role in malignant hyperthermia (MH), a syndrome caused by excessive Ca2+ release in skeletal muscle. Incidence of mortality in male calsequestrin-1 knockout (CASQ1-null) mice during exposure… read more here.
Keywords: mice lethal; muscle; calsequestrin knockout; stress ... See more keywords
Pneumococcal Surface Protein A-Hybrid Nanoparticles Protect Mice from Lethal Challenge after Mucosal Immunization Targeting the Lungs
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DOI: 10.3390/pharmaceutics14061238
Abstract: Pneumococcal disease remains a global burden, with current conjugated vaccines offering protection against the common serotype strains. However, there are over 100 serotype strains, and serotype replacement is now being observed, which reduces the effectiveness… read more here.
Keywords: mucosal immunization; pspa; hcl; mice lethal ... See more keywords