Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105590
Abstract: Aiming to develop novel allosteric autotaxin (ATX) inhibitors, hybrid strategy was utilized by assembling the benzyl carbamate fragment in PF-8380 onto the imidazo[1,2-a]pyridine skeleton of GLPG-1690. The piperazine moiety in GLPG-1690 was replaced with phenyl… read more here.
Keywords: imidazo pyridine; mice lung; glpg 1690; vivo ... See more keywords
Gas6 or Mer deficiency ameliorates silica-induced autophagosomes accumulation in mice lung.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.11.013
Abstract: Published evidences have shown that autophagy plays an important role in silica-induced lung inflammation and collagen deposition. Our previous study found that the level of growth arrest-specific protein 6 (Gas6) in bronchoalveolar lavage fluid was… read more here.
Keywords: gas6; autophagosomes accumulation; mer; silica induced ... See more keywords
Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.903157
Abstract: Cachexia is a debilitating comorbidity affecting many lung cancer patients. We have previously found that cachectic mice with lung cancer have reduced serum ketone body levels due to low PPARĪ± activity in the liver. Restoring… read more here.
Keywords: lung cancer; ketone; mice lung; mice ... See more keywords