Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3.
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DOI: 10.1016/j.atherosclerosis.2017.12.025
Abstract: BACKGROUND AND AIMS Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaque calcification… read more here.
Keywords: ldlr mice; trpc3; mice macrophage; calcification ... See more keywords