Mice and Rats Exhibit Striking Inter-species Differences in Gene Response to Acute Stroke.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01138-8
Abstract: Neuroprotection in acute stroke has not been successfully translated from animals to humans. Animal research on promising agents continues largely in rats and mice which are commonly available to researchers. However, controversies continue on the… read more here.
Keywords: response; mice rats; acute stroke; gene ... See more keywords
Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.03.023
Abstract: ABSTRACT A physiologically based pharmacokinetic (PBPK) model for hexavalent chromium [Cr(VI)] in mice, rats, and humans developed previously (Kirman et al., 2012, 2013), was updated to reflect an improved understanding of the toxicokinetics of the… read more here.
Keywords: rats humans; based pharmacokinetic; mice rats; physiologically based ... See more keywords
Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effects of FcRn Inhibitors in Mice, Rats, and Monkeys.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.065
Abstract: There is a growing interest in developing inhibitors of the neonatal Fc-receptor, FcRn, for use in the treatment for humoral autoimmune conditions. We have developed a new physiologically based pharmacokinetic model that is capable of… read more here.
Keywords: based pharmacokinetic; mice rats; anti fcrn; physiologically based ... See more keywords
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine.
Sign Up to like & getrecommendations! Published in 2022 at "Nature biomedical engineering"
DOI: 10.1038/s41551-022-00870-w
Abstract: Peripheral neurons that sense glucose relay signals of glucose availability to integrative clusters of neurons in the brain. However, the roles of such signalling pathways in the maintenance of glucose homoeostasis and their contribution to… read more here.
Keywords: glucose homoeostasis; nerve plexus; focused ultrasound; homoeostasis ... See more keywords
Controversial study says U.S. labs use 111 million mice, rats.
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.371.6527.332
Abstract: The most numerous animals in U.S. research are also the most invisible. Mice and rats comprise the vast majority of lab mammals, yet no one knows exactly—or even approximately—how many are used in scientific experiments… read more here.
Keywords: controversial study; mice rats; mice; million mice ... See more keywords
Gold Nanoparticle Toxicity in Mice and Rats: Species Differences
Sign Up to like & getrecommendations! Published in 2018 at "Toxicologic Pathology"
DOI: 10.1177/0192623318770608
Abstract: Nanotoxicity studies are greatly needed to advance nanomedical technologies into clinical practice. We assessed the toxic effects of a single intravenous exposure to commercially available gold nanoparticles (GNPs) in mice and rats. Fifteen-nm GNPs were… read more here.
Keywords: gold nanoparticle; nanoparticle toxicity; mice rats; gnps ... See more keywords
Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01832-2
Abstract: Background Production of inflammatory mediators by reactive microglial cells in the brain is generally considered the primary mechanism underlying the development of symptoms of sickness in response to systemic inflammation. Methods Depletion of microglia was… read more here.
Keywords: mice rats; inflammation; induced sickness; microglia depletion ... See more keywords
Considerations of Timing Post-ovariectomy in Mice and Rats in Studying Anxiety- and Depression-Like Behaviors Associated With Surgical Menopause in Women
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.829274
Abstract: Citation: Rodríguez-Landa JF (2022) Considerations of Timing Post-ovariectomy in Mice and Rats in Studying Anxietyand Depression-Like Behaviors Associated With Surgical Menopause in Women. Front. Behav. Neurosci. 16:829274. doi: 10.3389/fnbeh.2022.829274 Considerations of Timing Post-ovariectomy in Mice… read more here.
Keywords: rats studying; ovariectomy mice; timing post; mice rats ... See more keywords
Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1143109
Abstract: Experimental craniotomies are a common surgical procedure in neuroscience. Because inadequate analgesia appears to be a problem in animal-based research, we conducted this review and collected information on management of craniotomy-associated pain in laboratory mice… read more here.
Keywords: analgesia; 2009 2019; review; mice rats ... See more keywords
The “WWHow” Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.841431
Abstract: The prospective severity assessment in animal experiments in the categories' non-recovery, mild, moderate, and severe is part of each approval process and serves to estimate the harm/benefit. Harms are essential for evaluating ethical justifiability, and… read more here.
Keywords: wwhow concept; severity assessment; mice rats; severity ... See more keywords
Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23062918
Abstract: Purpose: The lack of suitable animal models for (dry) age-related macular degeneration (AMD) has hampered therapeutic research into the disease, so far. In this study, pigmented rats and mice were systematically injected with various doses… read more here.
Keywords: injection; iodate injection; sodium iodate; retinal degenerative ... See more keywords