Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice
Sign Up to like & getrecommendations! Published in 2019 at "Translational Psychiatry"
DOI: 10.1038/s41398-018-0344-y
Abstract: SETD5, a gene linked to intellectual disability (ID) and autism spectrum disorder (ASD), is a member of the SET-domain family and encodes a putative histone methyltransferase (HMT). To date, the mechanism by which SETD5 haploinsufficiency… read more here.
Keywords: network; mice setd5; haploinsufficiency; like behaviors ... See more keywords
Neurobehavioral characteristics of mice with SETD5 mutations as models of IDD23 and KBG syndromes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1022339
Abstract: Genomic analysis has revealed that the genes for various chromatin regulators are mutated in many individuals with neurodevelopmental disorders (NDDs), emphasizing the important role of chromatin regulation in nervous system development and function. Chromatin regulation… read more here.
Keywords: neurobehavioral characteristics; mutations models; idd23 kbg; setd5 mutations ... See more keywords