Abstract LB336: pH-sensitive polymeric micelles loading IL-12 profoundly inflame the tumor microenvironment to eradicate cold tumors
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DOI: 10.1158/1538-7445.am2023-lb336
Abstract: Background: Treatment of immunologically cold tumors is a major challenge. IL-12 can activates both innate and adaptive immunity to elicit strong antitumor immunity. Nevertheless, the poor pharmacokinetic and severe side effects of IL-12 limit the… read more here.
Keywords: micelles loading; cold tumors; eradicate cold; sensitive polymeric ... See more keywords