Re‐Investigation of Hydration Potential of Rhodococcus Whole‐Cell Biocatalysts towards Michael Acceptors
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DOI: 10.1002/cctc.201901606
Abstract: The implementation of a stereoselective Michael addition with water as substrate is still a major challenge by classical, chemical means. Inspired by nature's ability to carry out this attractive reaction with both high selectivity and… read more here.
Keywords: michael; hydration potential; investigation hydration; michael acceptors ... See more keywords
Exploring Partners for the Domino α‐Arylation/Michael Addition Reaction Leading to Tetrahydroisoquinolines
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DOI: 10.1002/ejoc.201601300
Abstract: Sulfonates, sulfonamides and phosphonates are useful nucleophiles for palladium-catalyzed intramolecular alfa-arylation leading to tetrahydroisoquinolines. While the sulfonate alfa-arylation can be successfully combined in a domino process with a broad range of Michael acceptors, only vinyl… read more here.
Keywords: michael; partners domino; domino arylation; exploring partners ... See more keywords
Fluorinated Chiral Pyrans Obtained via Mechanochemical Organocatalytic Michael/oxa‐Michael Cascade
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DOI: 10.1002/ejoc.202400588
Abstract: Fluorine‐containing compounds are important in medicine or crop‐protection. Herein, we show asymmetric organocatalytic Michael/oxa‐Michael cascade leading to chiral fluorinated pyrans under mechanochemical conditions. Formal oxa‐Diels‐Alder reaction between fluorine containing unsaturated keto esters and β,γ‐unsaturated ketones… read more here.
Keywords: michael; michael oxa; fluorinated chiral; oxa michael ... See more keywords
Base‐Mediated Diastereoselective Aza/Oxa‐Michael Approach to Spiro‐Pyrazolone and Spiro‐Oxindole Derivatives Through [4 + 2] Spiro‐Annulation
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DOI: 10.1002/ejoc.202500881
Abstract: A metal‐free, base‐catalyzed double Michael diastereoselective [4 + 2] annulation reaction of para‐quinone methides with alkylidene pyrazolones and isatin‐derived N‐Boc ketimines or isatylidine malonitriles has been developed, leading to biologically inspired spiro‐heterocyclic derivatives under mild reaction conditions… read more here.
Keywords: michael; base mediated; annulation; diastereoselective aza ... See more keywords
Acknowledgement to Referees
Sign Up to like & getrecommendations! Published in 2021 at "Paediatric Drugs"
DOI: 10.1007/s40272-021-00479-7
Abstract: A Mixed-Methods Analysis of Medication Safety Incidents Reported in Neonatal and Children's Intensive Care. Gregory Aaen, USA Daoud Al-Badriyeh, Qatar Samuel Alperin, USA Doralina L. Anghelescu, USA Michael Auerbach, USA Pascal Augustin, France Tadej Avcin,… read more here.
Keywords: michael; germany; canada; italy ... See more keywords
Jorgensen–Hayashi organocatalyst/Brønsted acid-tethered multifunctional polymeric nanospheres for complex asymmetric multicomponent/multicatalysed organocatalysis: Heterogeneous Michael/Michael/aldol organocascade and [4+2] cycloaddition reactions
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2017.09.034
Abstract: Abstract Heterogeneous multicomponent/multicatalysed asymmetric organocascade reaction in green manner is a challenging task owing to mass transfer limitation and cooperative catalysis of double or multiple catalysts. In this work, a novel type of nanosphere-supported multifunctional… read more here.
Keywords: multicomponent multicatalysed; michael michael; michael; aldol organocascade ... See more keywords
Lewis acid-promoted cascade reaction for the synthesis of Michael acceptors and its application in a dimerization reaction
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DOI: 10.1016/j.tet.2017.05.017
Abstract: Abstract An efficient Lewis acid-promoted cascade reaction with dimethyl sulfoxide as a methylene source for the synthesis of Michael acceptors is reported. The key to developing this procedure is the selection of a mild base… read more here.
Keywords: michael; lewis acid; cascade reaction; promoted cascade ... See more keywords
Stereoselective synthesis of novel C-3 functionalized 3-sulfonyl-β-lactams: Promising biologically active heterocyclic scaffolds
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DOI: 10.1016/j.tetlet.2017.02.011
Abstract: Abstract An efficient and operationally simple strategy for the stereoselective synthesis of novel C -3 functionalized 3-sulfonyl-β-lactam heterocycles is described. The C -3 functionalized 3-phenyl/benzylsulfonyl-β-lactams 3/3′, 5/5′ has been synthesized via Michael addition using different… read more here.
Keywords: synthesis novel; michael; stereoselective synthesis; functionalized sulfonyl ... See more keywords
Diastereoselective direct amidation/aza-Michael cascade reaction to synthesize cis-1,3-disubstituted isoindolines
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DOI: 10.1016/j.tetlet.2020.152122
Abstract: Abstract A convenient and efficient base-promoted cascade reaction for the synthesis of cis-1,3-disubstituted isoindolines has been reported herein. We discovered that various N-protected imines bearing a Michael acceptor react smoothly with several nitrogenous nucleophiles in… read more here.
Keywords: cis disubstituted; michael; cascade reaction; disubstituted isoindolines ... See more keywords
PARALLELS AND DIVERGENCES: THREE CASE STUDIES IN THE MUSIC OF MICHAEL HERSCH
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DOI: 10.1017/s0040298222001127
Abstract: Abstract This article focuses on three recent works by the American composer Michael Hersch: the script of storms (2018), for soprano and orchestra, the chamber opera Poppaea (2019) and the 11-hour trilogy of works that… read more here.
Keywords: three case; divergences three; case studies; michael hersch ... See more keywords
MICHAEL TIPPETT'S ‘LOST’ PRISON LETTER
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DOI: 10.1017/s004029822400069x
Abstract: The letters sent by the English composer Michael Tippett from Wormwood Scrubs Prison, where, a conscientious objector, he spent two months in summer 1943, form a remarkable and important sequence, illuminating not only Tippett's life… read more here.
Keywords: michael; letter; lost prison; michael tippett ... See more keywords