Re‐Investigation of Hydration Potential of Rhodococcus Whole‐Cell Biocatalysts towards Michael Acceptors
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201901606
Abstract: The implementation of a stereoselective Michael addition with water as substrate is still a major challenge by classical, chemical means. Inspired by nature's ability to carry out this attractive reaction with both high selectivity and… read more here.
Keywords: michael; hydration potential; investigation hydration; michael acceptors ... See more keywords
Exploring Partners for the Domino α‐Arylation/Michael Addition Reaction Leading to Tetrahydroisoquinolines
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601300
Abstract: Sulfonates, sulfonamides and phosphonates are useful nucleophiles for palladium-catalyzed intramolecular alfa-arylation leading to tetrahydroisoquinolines. While the sulfonate alfa-arylation can be successfully combined in a domino process with a broad range of Michael acceptors, only vinyl… read more here.
Keywords: michael; partners domino; domino arylation; exploring partners ... See more keywords
Acknowledgement to Referees
Sign Up to like & getrecommendations! Published in 2021 at "Paediatric Drugs"
DOI: 10.1007/s40272-021-00479-7
Abstract: A Mixed-Methods Analysis of Medication Safety Incidents Reported in Neonatal and Children's Intensive Care. Gregory Aaen, USA Daoud Al-Badriyeh, Qatar Samuel Alperin, USA Doralina L. Anghelescu, USA Michael Auerbach, USA Pascal Augustin, France Tadej Avcin,… read more here.
Keywords: michael; germany; canada; italy ... See more keywords
Jorgensen–Hayashi organocatalyst/Brønsted acid-tethered multifunctional polymeric nanospheres for complex asymmetric multicomponent/multicatalysed organocatalysis: Heterogeneous Michael/Michael/aldol organocascade and [4+2] cycloaddition reactions
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2017.09.034
Abstract: Abstract Heterogeneous multicomponent/multicatalysed asymmetric organocascade reaction in green manner is a challenging task owing to mass transfer limitation and cooperative catalysis of double or multiple catalysts. In this work, a novel type of nanosphere-supported multifunctional… read more here.
Keywords: multicomponent multicatalysed; michael michael; michael; aldol organocascade ... See more keywords
Lewis acid-promoted cascade reaction for the synthesis of Michael acceptors and its application in a dimerization reaction
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.05.017
Abstract: Abstract An efficient Lewis acid-promoted cascade reaction with dimethyl sulfoxide as a methylene source for the synthesis of Michael acceptors is reported. The key to developing this procedure is the selection of a mild base… read more here.
Keywords: michael; lewis acid; cascade reaction; promoted cascade ... See more keywords
Stereoselective synthesis of novel C-3 functionalized 3-sulfonyl-β-lactams: Promising biologically active heterocyclic scaffolds
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.02.011
Abstract: Abstract An efficient and operationally simple strategy for the stereoselective synthesis of novel C -3 functionalized 3-sulfonyl-β-lactam heterocycles is described. The C -3 functionalized 3-phenyl/benzylsulfonyl-β-lactams 3/3′, 5/5′ has been synthesized via Michael addition using different… read more here.
Keywords: synthesis novel; michael; stereoselective synthesis; functionalized sulfonyl ... See more keywords
Diastereoselective direct amidation/aza-Michael cascade reaction to synthesize cis-1,3-disubstituted isoindolines
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152122
Abstract: Abstract A convenient and efficient base-promoted cascade reaction for the synthesis of cis-1,3-disubstituted isoindolines has been reported herein. We discovered that various N-protected imines bearing a Michael acceptor react smoothly with several nitrogenous nucleophiles in… read more here.
Keywords: cis disubstituted; michael; cascade reaction; disubstituted isoindolines ... See more keywords
PARALLELS AND DIVERGENCES: THREE CASE STUDIES IN THE MUSIC OF MICHAEL HERSCH
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DOI: 10.1017/s0040298222001127
Abstract: Abstract This article focuses on three recent works by the American composer Michael Hersch: the script of storms (2018), for soprano and orchestra, the chamber opera Poppaea (2019) and the 11-hour trilogy of works that… read more here.
Keywords: three case; divergences three; case studies; michael hersch ... See more keywords
Synthesis of 7-Arylthiomethyl Dibenzo[b,d]azepines through Imidoylative Heck Cyclization and CPA-Catalyzed Thio-Michael Addition/Enantioselective Protonation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01217
Abstract: A chiral phosphoric acid-catalyzed thio-Michael addition/enantioselective protonation has been developed for the first time. The reaction applies 7-methylene-6-aryl-7H-dibenzo[b,d]azepines, products of Pd-catalyzed imidoylative Heck cyclization, as Michael acceptors in reactions with a wide range of aryl… read more here.
Keywords: michael; thio michael; michael addition; dibenzo azepines ... See more keywords
Rational Design of Chiral Tridentate Ligands: Bifunctional Cobalt(II) Complex/Hydrogen Bond for Enantioselective Michael Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01435
Abstract: Bifunctional chiral tridentate bis(pyrroloimidazolone)pyridine (PyBPI) ligands have been designed, synthesized, and applied in an asymmetric Michael addition. With a 0.05 mol % PyBPI-Co(II) complex, β,γ-unsaturated α-keto esters reacted with 4-hydroxycoumarin to give the adducts in… read more here.
Keywords: tridentate; chiral tridentate; tridentate ligands; michael ... See more keywords
Isothiourea-Catalyzed Enantioselective Michael Addition of Malonates to α,β-Unsaturated Aryl Esters
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c01486
Abstract: An enantioselective Michael addition of malonates to α,β-unsaturated para-nitrophenyl esters was achieved using the Lewis basic isothiourea HyperBTM, giving excellent levels of product enantioselectivity (up to >99:1 enantiomeric ratio) in good yields and with complete… read more here.
Keywords: addition malonates; malonates unsaturated; michael addition; enantioselective michael ... See more keywords