Re‐Investigation of Hydration Potential of Rhodococcus Whole‐Cell Biocatalysts towards Michael Acceptors
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201901606
Abstract: The implementation of a stereoselective Michael addition with water as substrate is still a major challenge by classical, chemical means. Inspired by nature's ability to carry out this attractive reaction with both high selectivity and… read more here.
Keywords: michael; hydration potential; investigation hydration; michael acceptors ... See more keywords
Mechanistic Investigations of Reactions of the Frustrated Lewis Pairs (Triarylphosphines/B(C6F5)3) with Michael Acceptors.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03868
Abstract: Frustrated Lewis pair (FLP)-catalyzed reduction of Michael acceptors is a challenging reaction that proceeds with specific FLP structures. Kinetics and equilibrium of the reactions of two phosphines (Ar3P), namely tri(1-naphthyl)phosphine and tri(o-tolyl)phosphine, are reported with… read more here.
Keywords: lewis pairs; investigations reactions; mechanistic investigations; reactions frustrated ... See more keywords
Cobalt Catalyzed Hydroarylation of Michael Acceptors with Indolines Directed by a Weakly Coordinating Functional Group.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01228
Abstract: A cobalt(III) catalyzed hydroarylation of Michael acceptors using indolines, selectively at the C-7 position, has been reported. For the selective C-7 functionalization of indoline, we have used a weakly coordinating amide carbonyl group. During the… read more here.
Keywords: hydroarylation; catalyzed hydroarylation; weakly coordinating; hydroarylation michael ... See more keywords
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00084
Abstract: Human African Trypanosomiasis (HAT) is a neglected tropical disease widespread in sub-Saharan Africa. Rhodesain, a cysteine protease of Trypanosoma brucei rhodesiense, has been identified as a valid target for the development of anti-HAT agents. Herein,… read more here.
Keywords: michael acceptors; bond containing; development; urea bond ... See more keywords
Electrophilic reactivities of cyclic enones and α,β-unsaturated lactones†
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d0sc06628a
Abstract: The reactivities of cyclic enones and α,β-unsaturated lactones were characterized by following the kinetics of their reactions with colored carbon-centered reference nucleophiles in DMSO at 20 °C. The experimentally determined second-order rate constants k2 were… read more here.
Keywords: unsaturated lactones; cyclic enones; enones unsaturated; reactivity ... See more keywords
Reactivities of allenic and olefinic Michael acceptors towards phosphines.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06786a
Abstract: The kinetics of the reactions of tributylphosphine with allenic and olefinic Michael acceptors in dichloromethane at 20 °C was followed by photometric and NMR spectroscopic methods. Combination with DFT-calculated methyl anion affinities revealed the relevance… read more here.
Keywords: olefinic michael; reactivities allenic; acceptors towards; allenic olefinic ... See more keywords
Cu-catalyzed carboboration of acetylene with Michael acceptors
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc02306g
Abstract: A copper-catalyzed three-component carboboration of acetylene with B2Pin2 and Michael acceptors is reported. In this reaction, a cheap and abundant C2 chemical feedstock, acetylene, was used as a starting material to afford cis-alkenyl boronates bearing… read more here.
Keywords: acetylene; michael acceptors; carboboration acetylene; catalyzed carboboration ... See more keywords
Insights into the Cobalt-Catalyzed Three-Component Coupling of Mixed Aromatic Organozinc Species, Carbonyl Compounds or Imines and Michael Acceptors: Synthetic and Mechanistic Aspects
Sign Up to like & getrecommendations! Published in 2018 at "Synthesis"
DOI: 10.1055/s-0036-1590957
Abstract: The first examples of cobalt-catalyzed multicomponent couplings of mixed aromatic arylzinc reagents with Michael acceptors and carbonyl compounds or imines is described. The reaction system employs a cobalt(II)-2,2′-bipyridine or a cobalt(II)-1,10-phenanthroline complex as a catalyst… read more here.
Keywords: cobalt; cobalt catalyzed; carbonyl compounds; compounds imines ... See more keywords
Enhanced Activity of the Tail-to-tail Dimerization of Michael Acceptors Catalyzed by N-Heterocyclic Carbene and Subsequent Polymer Synthesis from the Resulting Dimers
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry Letters"
DOI: 10.1246/cl.190097
Abstract: In this study, the efficiency of tail-to-tail dimerization of Michael acceptors catalyzed by N-heterocyclic carbene has been significantly improved. By increasing the reaction temperature to 200 °C... read more here.
Keywords: dimerization michael; acceptors catalyzed; michael acceptors; tail dimerization ... See more keywords
Catalyst-Free Formal Conjugate Addition/Aldol or Mannich Multicomponent Reactions of Mixed Aliphatic Organozinc Reagents, π-Electrophiles and Michael Acceptors
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031401
Abstract: Catalyst-free multicomponent reactions of mixed alkylzinc reagents with Michael acceptors and aldehydes, ketones or activated imines are described. Primary, secondary and tertiary alkylzinc reagents, pre-generated in acetonitrile from the corresponding iodoalkanes, were used in the… read more here.
Keywords: reactions mixed; addition; michael acceptors; multicomponent reactions ... See more keywords