Re‐Investigation of Hydration Potential of Rhodococcus Whole‐Cell Biocatalysts towards Michael Acceptors
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201901606
Abstract: The implementation of a stereoselective Michael addition with water as substrate is still a major challenge by classical, chemical means. Inspired by nature's ability to carry out this attractive reaction with both high selectivity and… read more here.
Keywords: michael; hydration potential; investigation hydration; michael acceptors ... See more keywords
Mechanistic Investigations of Reactions of the Frustrated Lewis Pairs (Triarylphosphines/B(C6F5)3) with Michael Acceptors.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03868
Abstract: Frustrated Lewis pair (FLP)-catalyzed reduction of Michael acceptors is a challenging reaction that proceeds with specific FLP structures. Kinetics and equilibrium of the reactions of two phosphines (Ar3P), namely tri(1-naphthyl)phosphine and tri(o-tolyl)phosphine, are reported with… read more here.
Keywords: lewis pairs; investigations reactions; mechanistic investigations; reactions frustrated ... See more keywords
Cobalt Catalyzed Hydroarylation of Michael Acceptors with Indolines Directed by a Weakly Coordinating Functional Group.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01228
Abstract: A cobalt(III) catalyzed hydroarylation of Michael acceptors using indolines, selectively at the C-7 position, has been reported. For the selective C-7 functionalization of indoline, we have used a weakly coordinating amide carbonyl group. During the… read more here.
Keywords: hydroarylation; catalyzed hydroarylation; weakly coordinating; hydroarylation michael ... See more keywords
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00084
Abstract: Human African Trypanosomiasis (HAT) is a neglected tropical disease widespread in sub-Saharan Africa. Rhodesain, a cysteine protease of Trypanosoma brucei rhodesiense, has been identified as a valid target for the development of anti-HAT agents. Herein,… read more here.
Keywords: michael acceptors; bond containing; development; urea bond ... See more keywords
Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c02128
Abstract: Current FDA-approved proteasome inhibitor (PI) drugs, such as bortezomib, carfilzomib, and ixazomib, have significantly improved the treatment of multiple myeloma (MM) over the past 20 years. However, due to their associated severe side effects and… read more here.
Keywords: proteasome; aza peptide; michael acceptors; peptide michael ... See more keywords
Electrophilic reactivities of cyclic enones and α,β-unsaturated lactones†
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d0sc06628a
Abstract: The reactivities of cyclic enones and α,β-unsaturated lactones were characterized by following the kinetics of their reactions with colored carbon-centered reference nucleophiles in DMSO at 20 °C. The experimentally determined second-order rate constants k2 were… read more here.
Keywords: unsaturated lactones; cyclic enones; enones unsaturated; reactivity ... See more keywords
Reactivities of allenic and olefinic Michael acceptors towards phosphines.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06786a
Abstract: The kinetics of the reactions of tributylphosphine with allenic and olefinic Michael acceptors in dichloromethane at 20 °C was followed by photometric and NMR spectroscopic methods. Combination with DFT-calculated methyl anion affinities revealed the relevance… read more here.
Keywords: olefinic michael; reactivities allenic; acceptors towards; allenic olefinic ... See more keywords
Cu-catalyzed carboboration of acetylene with Michael acceptors
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DOI: 10.1039/d2sc02306g
Abstract: A copper-catalyzed three-component carboboration of acetylene with B2Pin2 and Michael acceptors is reported. In this reaction, a cheap and abundant C2 chemical feedstock, acetylene, was used as a starting material to afford cis-alkenyl boronates bearing… read more here.
Keywords: acetylene; michael acceptors; carboboration acetylene; catalyzed carboboration ... See more keywords
Insights into the Cobalt-Catalyzed Three-Component Coupling of Mixed Aromatic Organozinc Species, Carbonyl Compounds or Imines and Michael Acceptors: Synthetic and Mechanistic Aspects
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DOI: 10.1055/s-0036-1590957
Abstract: The first examples of cobalt-catalyzed multicomponent couplings of mixed aromatic arylzinc reagents with Michael acceptors and carbonyl compounds or imines is described. The reaction system employs a cobalt(II)-2,2′-bipyridine or a cobalt(II)-1,10-phenanthroline complex as a catalyst… read more here.
Keywords: cobalt; cobalt catalyzed; carbonyl compounds; compounds imines ... See more keywords
Enhanced Activity of the Tail-to-tail Dimerization of Michael Acceptors Catalyzed by N-Heterocyclic Carbene and Subsequent Polymer Synthesis from the Resulting Dimers
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry Letters"
DOI: 10.1246/cl.190097
Abstract: In this study, the efficiency of tail-to-tail dimerization of Michael acceptors catalyzed by N-heterocyclic carbene has been significantly improved. By increasing the reaction temperature to 200 °C... read more here.
Keywords: dimerization michael; acceptors catalyzed; michael acceptors; tail dimerization ... See more keywords
Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality?
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116099
Abstract: Michael acceptors represent a class of compounds with potential anti-cancer properties. They act by binding to nucleophilic sites in biological molecules, thereby disrupting cancer cell function and inducing cell death. This mode of action, as… read more here.
Keywords: cancer; cancer compounds; anti cancer; acceptors anti ... See more keywords