Low‐Defect Thiol‐Michael Addition Hydrogels as Matrigel Substitutes for Epithelial Organoid Derivation
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202000761
Abstract: Due to their selective crosslinking chemistry and well‐defined mechano‐biochemical characteristics, hydrogels crosslinked by thiol‐Michael addition reactions have garnered immense interest for 3D cell culture applications. These hydrogels are typically formed via end‐linking of bis‐cysteine oligopeptides… read more here.
Keywords: defect thiol; thiol michael; low defect; michael addition ... See more keywords
The Effect of Dextran Molecular Weight on the Biodegradable Hydrogel with Oil, Synthesized by the Michael Addition Reaction
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Polymer Technology"
DOI: 10.1002/adv.21871
Abstract: Plant oil and derivatives have been used in polymer biomaterials, especially as starting materials for the synthesis of bio-based polymers. The uses have many advantages such as biodegradability, renewability, energy saving, easy of production, less… read more here.
Keywords: addition reaction; michael addition; oil; dextran ... See more keywords
Current Developments in Michael Addition Reaction using Heterocycles as Convenient Michael Donors
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400193
Abstract: The Michael addition reaction, a cornerstone of contemporary organic synthesis, has witnessed a resurgence of interest owing to its ability to forge intricate carbon‐carbon and carbon‐heteroatom bonds. In the past few years, heterocyclic compounds have… read more here.
Keywords: michael addition; chemistry; addition reaction; michael donors ... See more keywords
Diastereoselective Michael Addition of Non‐Functionalized Furanone to Nitroalkenes in Aqueous Condition
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202500354
Abstract: Selectivity plays a major role in organic chemistry and biological applications. Herein, we present a diastereoselective DMAP‐catalyzed Michael addition of furanone (butenolide) to nitroalkenes. Notably, our method does not require the pre‐activation of furanone as… read more here.
Keywords: michael addition; furanone; chemistry; diastereoselective michael ... See more keywords
New bifunctional 1,3-diamine organocatalysts derived from (+)-camphoric acid for asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefins.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23424
Abstract: Novel 1,3-diamine-derived bifunctional thiourea and squaramide organocatalysts were synthesized from (+)-camphoric acid. These catalysts were easily obtained in up to two to five synthetic steps, in a flexible approach that facilitates their structure variation. Their… read more here.
Keywords: addition dicarbonyl; asymmetric michael; michael addition; camphoric acid ... See more keywords
Chiral C2 -symmetric bis-thioureas as enzyme mimics in enantioselective Michael addition.
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DOI: 10.1002/chir.23438
Abstract: We report herein the synthesis and application of enantiopure C2 -symmetric primary amine-1,3-bis-thiourea organocatalysts in enantioselective conjugate 1,4-Michael addition of carbonyl containing nucleophiles, to nitroalkenes and N-phenylmaleimide, leading to final products in good enantioselectivities (up… read more here.
Keywords: bis; bis thioureas; michael addition; chiral symmetric ... See more keywords
Organocatalytic Asymmetric Sulfa‐Michael Addition of 2‐Aminothiophenols to Chalcones: First Enantioselective Access to 2,3,4,5‐Tetrahydro‐1,5‐benzothiazepines
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601364
Abstract: 1,5-Benzothiazepine frameworks are highly relevant in medicinal chemistry. Reported catalytic asymmetric approaches to these scaffolds have targeted 2,3-dihydro-1,5-benzothiazepin-4-ones, leaving the corresponding amines (2,3,4,5-tetrahydro-1,5-benzo-thiazepines) out of reach. Herein, we present the first entry to these important… read more here.
Keywords: addition aminothiophenols; sulfa michael; michael addition; chemistry ... See more keywords
A Sequential Nitro‐Michael Addition and Reductive Cyclization Cascade Reaction for Diastereoselective Synthesis of Multifunctionalized 3,3'‐pyrrolidinyl‐spirooxindoles
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DOI: 10.1002/ejoc.202401121
Abstract: In this investigation, we elucidated, one‐pot two stage efficient synthesis of multifuctionalized spiro[oxindole ‐3,3′‐pyrrolidine]. The methodology proceeds via organocatalyzed nitro‐Michael addition reaction between indolylidenecyanoesters and nitroalkanes to formed nitro‐Michael adduct which transformed into multifunctionalized 3,3'‐pyrrolidinyl‐spirooxindoles… read more here.
Keywords: reaction; michael addition; pyrrolidinyl spirooxindoles; multifunctionalized pyrrolidinyl ... See more keywords
Salt‐Free CatAnionic Vesicular Nanoreactor from Dithiocarbamate: Michael Addition of Nitroolefins in Water
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500770
Abstract: The salt‐free CatAnionic vesicle is previously generated by mixing cationic and anionic amphiphiles and removing the salt that occurred as a byproduct from the mixture. In this study, a new strategy to produce the salt‐free… read more here.
Keywords: michael addition; amdtc c12; free catanionic; vesicular nanoreactor ... See more keywords
Organocatalytic Cascade Knoevenagel–Michael Addition Reactions: Direct Synthesis of Polysubstituted 2-Amino-4H-Chromene Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Catalysis Letters"
DOI: 10.1007/s10562-019-03089-8
Abstract: In this report, we documented novel strategy for the synthesis of bioactive polysubstituted 2-amino-4H-chromine derivatives under a heterogeneous Al-MCM-41-LDH@APTES (ALAM) catalysis. A synthetic procedure is developed to prepare Al-MCM-41-LDH@APTES (ALAM) heterogeneous basic catalysts. Mesoporous Al-MCM-41… read more here.
Keywords: synthesis polysubstituted; michael addition; polysubstituted amino; addition reactions ... See more keywords
Michael Addition of 1,3-Dicarbonyl Derivatives in the Presence of Zeolite Y as an Heterogeneous Catalyst
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DOI: 10.1007/s10904-019-01424-5
Abstract: This paper focuses on the preparation and modification of zeolite Y by different methods. The obtained samples were characterized by X-ray diffraction, X-ray fluorescence, nitrogen adsorption–desorption and zeta potential measurements. The obtained catalysts were tested… read more here.
Keywords: addition; derivatives presence; michael addition; addition dicarbonyl ... See more keywords