Low‐Defect Thiol‐Michael Addition Hydrogels as Matrigel Substitutes for Epithelial Organoid Derivation
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DOI: 10.1002/adfm.202000761
Abstract: Due to their selective crosslinking chemistry and well‐defined mechano‐biochemical characteristics, hydrogels crosslinked by thiol‐Michael addition reactions have garnered immense interest for 3D cell culture applications. These hydrogels are typically formed via end‐linking of bis‐cysteine oligopeptides… read more here.
Keywords: defect thiol; thiol michael; low defect; michael addition ... See more keywords
The Effect of Dextran Molecular Weight on the Biodegradable Hydrogel with Oil, Synthesized by the Michael Addition Reaction
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Polymer Technology"
DOI: 10.1002/adv.21871
Abstract: Plant oil and derivatives have been used in polymer biomaterials, especially as starting materials for the synthesis of bio-based polymers. The uses have many advantages such as biodegradability, renewability, energy saving, easy of production, less… read more here.
Keywords: addition reaction; michael addition; oil; dextran ... See more keywords
New bifunctional 1,3-diamine organocatalysts derived from (+)-camphoric acid for asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefins.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23424
Abstract: Novel 1,3-diamine-derived bifunctional thiourea and squaramide organocatalysts were synthesized from (+)-camphoric acid. These catalysts were easily obtained in up to two to five synthetic steps, in a flexible approach that facilitates their structure variation. Their… read more here.
Keywords: addition dicarbonyl; asymmetric michael; michael addition; camphoric acid ... See more keywords
Chiral C2 -symmetric bis-thioureas as enzyme mimics in enantioselective Michael addition.
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DOI: 10.1002/chir.23438
Abstract: We report herein the synthesis and application of enantiopure C2 -symmetric primary amine-1,3-bis-thiourea organocatalysts in enantioselective conjugate 1,4-Michael addition of carbonyl containing nucleophiles, to nitroalkenes and N-phenylmaleimide, leading to final products in good enantioselectivities (up… read more here.
Keywords: bis; bis thioureas; michael addition; chiral symmetric ... See more keywords
Organocatalytic Asymmetric Sulfa‐Michael Addition of 2‐Aminothiophenols to Chalcones: First Enantioselective Access to 2,3,4,5‐Tetrahydro‐1,5‐benzothiazepines
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601364
Abstract: 1,5-Benzothiazepine frameworks are highly relevant in medicinal chemistry. Reported catalytic asymmetric approaches to these scaffolds have targeted 2,3-dihydro-1,5-benzothiazepin-4-ones, leaving the corresponding amines (2,3,4,5-tetrahydro-1,5-benzo-thiazepines) out of reach. Herein, we present the first entry to these important… read more here.
Keywords: addition aminothiophenols; sulfa michael; michael addition; chemistry ... See more keywords
Organocatalytic Cascade Knoevenagel–Michael Addition Reactions: Direct Synthesis of Polysubstituted 2-Amino-4H-Chromene Derivatives
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DOI: 10.1007/s10562-019-03089-8
Abstract: In this report, we documented novel strategy for the synthesis of bioactive polysubstituted 2-amino-4H-chromine derivatives under a heterogeneous Al-MCM-41-LDH@APTES (ALAM) catalysis. A synthetic procedure is developed to prepare Al-MCM-41-LDH@APTES (ALAM) heterogeneous basic catalysts. Mesoporous Al-MCM-41… read more here.
Keywords: synthesis polysubstituted; michael addition; polysubstituted amino; addition reactions ... See more keywords
Michael Addition of 1,3-Dicarbonyl Derivatives in the Presence of Zeolite Y as an Heterogeneous Catalyst
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DOI: 10.1007/s10904-019-01424-5
Abstract: This paper focuses on the preparation and modification of zeolite Y by different methods. The obtained samples were characterized by X-ray diffraction, X-ray fluorescence, nitrogen adsorption–desorption and zeta potential measurements. The obtained catalysts were tested… read more here.
Keywords: addition; derivatives presence; michael addition; addition dicarbonyl ... See more keywords
Synthesis of chiral α-carbonyl-δ-nitro-ketenedithioacetals via l-proline-catalyzed Michael addition reaction
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-017-3025-1
Abstract: Regioselective synthesis of 1,1-bis(methylthio)-6-nitro-5-arylhex-1-en-3-one has been achieved from α-alkenoylketene dithioacetals with nitromethane using l-proline catalyst via Michael addition. The synthesized compounds 3a–j were well characterised by NMR and mass spectral techniques. One of the structures… read more here.
Keywords: nitro ketenedithioacetals; addition; synthesis chiral; michael addition ... See more keywords
Graphene Film-Supported Oriented 1.1.1 Gold(0) Versus 2.0.0 Copper(I) Nanoplatelets as Very Efficient Catalysts for Coupling Reactions
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DOI: 10.1007/s11244-018-1043-x
Abstract: Few-layered graphene-supported 1.1.1 and 2.0.0 oriented Au and Cu2O nanoplatelets were prepared by one-step pyrolysis of the corresponding metal salts embedded in chitosan at 900 °C under inert atmosphere. These nanometric films containing oriented nanoplatelets were… read more here.
Keywords: graphene film; michael addition; graphene; supported oriented ... See more keywords
Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides
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DOI: 10.1007/s11426-018-9393-2
Abstract: A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3- substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3′-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were… read more here.
Keywords: quinine derived; michael addition; enantioselective michael; substituted phthalides ... See more keywords
A facile synthetic approach to 3-halo-4-substituted-1,5-dihydro-4 H -1,2,4-triazoline-5-thiones based on retro-Michael addition
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-017-6491-5
Abstract: A facile 3-step synthetic approach to 3-halo-4-substituted-1,5-dihydro-4H-1,2,4-triazoline-5-thiones (1a—1k) from corresponding unhalogenated 8a—8i was developed based on the strategy of retro-Michael addition, with the key steps being regioselective S-alkylation of compounds 8a—8i with ethyl 3-iodopropionate(12c) and… read more here.
Keywords: synthetic approach; michael addition; retro michael;