Enantiocomplementary Michael Additions of Acetaldehyde to Aliphatic Nitroalkenes Catalyzed by Proline‐Based Carboligases
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DOI: 10.1002/cbic.202100644
Abstract: The blockbuster drug Pregabalin is widely prescribed for the treatment of painful diabetic neuropathy. Given the continuous epidemic growth of diabetes, the development of sustainable synthesis routes for Pregabalin and structurally related pharmaceutically active γ‐aminobutyric… read more here.
Keywords: enantiocomplementary michael; acetaldehyde aliphatic; additions acetaldehyde; michael additions ... See more keywords
Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates
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DOI: 10.1021/acscatal.9b00780
Abstract: The enzyme 4-oxalocrotonate tautomerase (4-OT) exploits an N-terminal proline as main catalytic residue to facilitate several promiscuous C–C bond-forming reactions via enzyme-bound enamine intermediates. Here we show that the active site of this enzyme can… read more here.
Keywords: unsaturated aldehydes; enzyme bound; enzyme; asymmetric michael ... See more keywords
Development of Chiral, Bifunctional Thiosquaramides: Enantioselective Michael Additions of Barbituric Acids to Nitroalkenes.
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DOI: 10.1021/jacs.7b01115
Abstract: We report a general method for the synthesis of chiral thiosquaramides, a class of bifunctional catalysts not previously described in the literature. Thiosquaramides are found to be more acidic and significantly more soluble in nonpolar… read more here.
Keywords: thiosquaramides enantioselective; chiral bifunctional; enantioselective michael; bifunctional thiosquaramides ... See more keywords
A thiourea-functionalized metal-organic macrocycle for the catalysis of Michael additions and prominent size-selective effect.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c6dt04299f
Abstract: A discrete tetranuclear thiourea-based metal-organic macrocycle (MOM) with a large size was constructed by a well-designed organic ligand and nickel(ii) ions via self-assembly. Incorporating thiourea groups as hydrogen-bond donors into a metal-organic complex system leads… read more here.
Keywords: organic macrocycle; size; metal organic; michael additions ... See more keywords