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Published in 2017 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2017.09.034
Abstract: Abstract Heterogeneous multicomponent/multicatalysed asymmetric organocascade reaction in green manner is a challenging task owing to mass transfer limitation and cooperative catalysis of double or multiple catalysts. In this work, a novel type of nanosphere-supported multifunctional…
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Keywords:
multicomponent multicatalysed;
michael michael;
michael;
aldol organocascade ... See more keywords
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Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01411
Abstract: The N-heterocyclic carbene-catalyzed asymmetric Michael/aldol/lactamization cascade reaction of enals and indole-derived enones for the synthesis of functionalized cyclopenta[3,4]pyrroloindolones with four consecutive stereogenic centers has been achieved. The products were obtained in good yield with high…
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Keywords:
cascade reaction;
aldol lactamization;
carbene catalyzed;
lactamization cascade ... See more keywords
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Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02085
Abstract: Enantioselective synthesis of pyrazolone-fused spirocyclohexenols by the secondary amine-catalyzed cascade reaction of α,β-unsaturated aldehydes with α-arylidene pyrazolinones is reported. This formal [3 + 3] organocascade reaction proceeds through a vinylogous Michael-aldol sequence to furnish the…
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Keywords:
aldol cascade;
michael aldol;
organocatalytic enantioselective;
vinylogous michael ... See more keywords
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Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02962
Abstract: An organocatalyzed enantioselective Michael-Michael-Michael-aldol cascade reaction for the construction of cyclopentane fused spirooxindoles was achieved. The domino reaction provided the spirooxindoles with six contiguous stereocenters including a quaternary center in good yields (55-64%) with excellent…
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Keywords:
michael michael;
michael;
michael aldol;
enantioselective michael ... See more keywords
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Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c03373
Abstract: A bifunctional iminophosphorane (BIMP)-catalyzed method for the synthesis of densely functionalized cyclohexanols establishes five contiguous stereocenters (diastereoselection up to >20:1, enantioselectivity up to >99:1) in a Michael/aldol domino reaction between trisubstituted electrophilic alkenes and γ-nitroketones.…
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Keywords:
asymmetric michael;
michael aldol;
curtin hammett;
michael ... See more keywords
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Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra04325f
Abstract: A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and α-aryl-β-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities.
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Keywords:
aldol cascade;
dihydrothiophenes bearing;
sulfa michael;
functionalized dihydrothiophenes ... See more keywords
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Published in 2017 at "Synlett"
DOI: 10.1055/s-0036-1588976
Abstract: A simple primary-secondary diamine organocatalyst catalyzes the cascade Michael–aldol–dehydration of chalcones and unmodified ketones to produce substituted cyclohex-2-enones under mild conditions with good yields and high enantio- and/or diastereoselectivities. The success of the catalyst system…
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Keywords:
secondary diamine;
cascade michael;
substituted cyclohex;
primary secondary ... See more keywords