Articles with "michael aldol" as a keyword



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Jorgensen–Hayashi organocatalyst/Brønsted acid-tethered multifunctional polymeric nanospheres for complex asymmetric multicomponent/multicatalysed organocatalysis: Heterogeneous Michael/Michael/aldol organocascade and [4+2] cycloaddition reactions

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Published in 2017 at "Molecular Catalysis"

DOI: 10.1016/j.mcat.2017.09.034

Abstract: Abstract Heterogeneous multicomponent/multicatalysed asymmetric organocascade reaction in green manner is a challenging task owing to mass transfer limitation and cooperative catalysis of double or multiple catalysts. In this work, a novel type of nanosphere-supported multifunctional… read more here.

Keywords: multicomponent multicatalysed; michael michael; michael; aldol organocascade ... See more keywords
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Asymmetric Synthesis of Cyclopenta[3,4]pyrroloindolones via N-Heterocyclic Carbene-Catalyzed Michael/Aldol/Lactamization Cascade Reaction.

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Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b01411

Abstract: The N-heterocyclic carbene-catalyzed asymmetric Michael/aldol/lactamization cascade reaction of enals and indole-derived enones for the synthesis of functionalized cyclopenta[3,4]pyrroloindolones with four consecutive stereogenic centers has been achieved. The products were obtained in good yield with high… read more here.

Keywords: cascade reaction; aldol lactamization; carbene catalyzed; lactamization cascade ... See more keywords
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Organocatalytic Enantioselective Vinylogous Michael-Aldol Cascade for the Synthesis of Spirocyclic Compounds.

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Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b02085

Abstract: Enantioselective synthesis of pyrazolone-fused spirocyclohexenols by the secondary amine-catalyzed cascade reaction of α,β-unsaturated aldehydes with α-arylidene pyrazolinones is reported. This formal [3 + 3] organocascade reaction proceeds through a vinylogous Michael-aldol sequence to furnish the… read more here.

Keywords: aldol cascade; michael aldol; organocatalytic enantioselective; vinylogous michael ... See more keywords
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Organocatalytic Enantioselective Michael-Michael-Michael-Aldol Condensation Reactions: Control of Six Stereocenters in a Quadruple-Cascade Asymmetric Synthesis of Polysubstituted Spirocyclic Oxindoles.

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Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b02962

Abstract: An organocatalyzed enantioselective Michael-Michael-Michael-aldol cascade reaction for the construction of cyclopentane fused spirooxindoles was achieved. The domino reaction provided the spirooxindoles with six contiguous stereocenters including a quaternary center in good yields (55-64%) with excellent… read more here.

Keywords: michael michael; michael; michael aldol; enantioselective michael ... See more keywords
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Catalytic, Asymmetric Michael-Aldol Annulations via a Stereodivergent/Stereoconvergent Path Operating under Curtin-Hammett Control.

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Published in 2023 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.3c03373

Abstract: A bifunctional iminophosphorane (BIMP)-catalyzed method for the synthesis of densely functionalized cyclohexanols establishes five contiguous stereocenters (diastereoselection up to >20:1, enantioselectivity up to >99:1) in a Michael/aldol domino reaction between trisubstituted electrophilic alkenes and γ-nitroketones.… read more here.

Keywords: asymmetric michael; michael aldol; curtin hammett; michael ... See more keywords
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Organocatalytic sulfa-Michael/aldol cascade: constructing functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter

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Published in 2018 at "RSC Advances"

DOI: 10.1039/c8ra04325f

Abstract: A practical sulfa-Michael/aldol cascade reaction of 1,4-dithiane-2,5-diol and α-aryl-β-nitroacrylates has been developed, which allows efficient access to functionalized 2,5-dihydrothiophenes bearing a quaternary carbon stereocenter in moderate to good yields with high enantioselectivities. read more here.

Keywords: aldol cascade; dihydrothiophenes bearing; sulfa michael; functionalized dihydrothiophenes ... See more keywords

Primary-Secondary Diamine Catalyzed Enantioselective Synthesis of Substituted Cyclohex-2-enones by Cascade Michael–Aldol–­Dehydration of Ketones with Chalcones

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Published in 2017 at "Synlett"

DOI: 10.1055/s-0036-1588976

Abstract: A simple primary-secondary diamine organocatalyst catalyzes the cascade Michael–aldol–dehydration of chalcones and unmodified ketones to produce substituted cyclohex-2-enones under mild conditions with good yields and high enantio- and/or diastereoselectivities. The success of the catalyst system… read more here.

Keywords: secondary diamine; cascade michael; substituted cyclohex; primary secondary ... See more keywords