Imidazolium ylide mediated tandem Knoevenagel–Michael–O-cyclization sequence for the synthesis of multi-substituted 4,5-dihydrofurans
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2020.1821226
Abstract: Abstract The stereoselective syntheses of novel trans-5-aroyl-2,4-diaryl-4,5-dihydrofuran-3-carbonitriles have been achieved via a one-pot, three-component tandem protocol involving aroyl acetonitriles, aromatic aldehydes, and imidazolium ylide in the presence of Et3N. Graphical Abstract read more here.
Keywords: mediated tandem; michael cyclization; tandem knoevenagel; imidazolium ylide ... See more keywords
Michael Cyclization of Polarized Systems: Synthesis and in vitro Anti-Diabetic Evaluation of Some Novel Pyrimidine, Pyridine, Pyrazole and Pyrazolo[3,4-b ]pyridine Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Croatica Chemica Acta"
DOI: 10.5562/cca3122
Abstract: Various interesting heterocycle skeletons were synthesized via Michael type addition reaction with 1,2; 1,3-bidentate nitrogen and carbon nucleophiles. Cycloaddition of different α,β–unsaturated systems afforded bromopyrimidinone 3/5, bromothiazine 4 and bromopyrazole 6a/6b pyrazole-1-carboxylate 8, pyridinylmethanone 9,… read more here.
Keywords: pyrazole; pyridine; michael cyclization; polarized systems ... See more keywords