Desymmetrization Process by Mg(II)-Catalyzed Intramolecular Vinylogous Michael Reaction.
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DOI: 10.1021/acs.orglett.0c03417
Abstract: Chiral magnesium catalyzed intramolecular vinylogous Michael reaction of novel cyclohexadienones via a desymmetrization process is reported. (R)-BINOL derived ligand and an achiral amide were employed in the current in situ generated magnesium catalyst, giving the… read more here.
Keywords: vinylogous michael; michael reaction; intramolecular vinylogous; desymmetrization process ... See more keywords
Highly Diastereoselective Crown Ether Catalyzed Arylogous Michael Reaction of 3-Aryl Phthalides.
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DOI: 10.1021/acs.orglett.7b02113
Abstract: The first arylogous Michael reaction of 3-aryl phthalides has been developed. The reaction, promoted by catalytic amounts of KOH or K3PO4 and dibenzo-18-crown-6, affords the corresponding 3,3-disubstituted phthalides in good to high yields and as… read more here.
Keywords: crown; arylogous michael; aryl phthalides; michael reaction ... See more keywords
Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01535
Abstract: The highly reactive precursor molecule, presaccharothriolide X, was successfully isolated from the rare actinomycete Saccharothrix sp. A1506. The comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating… read more here.
Keywords: rare actinomycete; saccharothrix a1506; retro michael; michael reaction ... See more keywords
Porous Organic Polymer with Thiourea Linkages (POP-TU): An Effective and Recyclable Organocatalyst for Michael Reaction.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c01280
Abstract: As a novel porous organic polymer with thiourea linkages (POP-TU), POP-TU-1 and POP-TU-2 were successfully synthesized with tris(4-aminophenyl) amine (TAA) and 1,4-phenylene diisothiocyanate (PDT) in DMF and 1,4-dioxane, respectively. The as-synthesized POP-TU-1 and POP-TU-2 possess… read more here.
Keywords: polymer thiourea; organic polymer; thiourea linkages; porous organic ... See more keywords
Phosphine-Catalyzed Dual Umpolung Domino Michael Reaction: Facile Synthesis of Hydroindole- and Hydrobenzofuran-2-Carboxylates
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.8b01011
Abstract: A highly atom-economical, chemoselective, and stereoselective Lewis base (LB)-catalyzed dual umpolung domino Michael reaction between cyclohexadienones and alkynyl esters has been developed. PPh3, as a LB catalyst, afforded either the hydroindole-2-carboxylates or hydrobenzofuran-2-carboxylates 3 as… read more here.
Keywords: umpolung domino; hydrobenzofuran carboxylates; domino michael; catalyzed dual ... See more keywords
Catalytic Enantioselective Intramolecular Oxa-Michael Reaction to α,β-Unsaturated Esters and Amides.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c03182
Abstract: A bifunctional iminophosphorane (BIMP)-catalyzed, enantioselective intramolecular oxa-Michael reaction of alcohols to tethered, low electrophilicity Michael acceptors is described. Improved reactivity over previous reports (1 day vs 7 days), excellent yields (up to 99%), and enantiomeric… read more here.
Keywords: michael; reaction; michael reaction; oxa michael ... See more keywords
Thia-Michael Reaction: The Route to Promising Covalent Adaptable Networks
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DOI: 10.3390/polym14204457
Abstract: While the Michael addition has been employed for more than 130 years for the synthesis of a vast diversity of compounds, the reversibility of this reaction when heteronucleophiles are involved has been generally less considered.… read more here.
Keywords: reaction; adaptable networks; covalent adaptable; michael reaction ... See more keywords
Diastereoselective auxiliary- and catalyst-controlled intramolecular aza-Michael reaction for the elaboration of enantioenriched 3-substituted isoindolinones. Application to the synthesis of a new pazinaclone analogue
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.46
Abstract: A new asymmetric organocatalyzed intramolecular aza-Michael reaction by means of both a chiral auxiliary and a catalyst for stereocontrol is reported for the synthesis of optically active isoindolinones. A selected cinchoninium salt was used as… read more here.
Keywords: auxiliary catalyst; substituted isoindolinones; michael reaction; aza michael ... See more keywords