α-Nitro-α,β-Unsaturated Ketones: An Electrophilic Acyl Transfer Reagent in Catalytic Asymmetric Friedel-Crafts and Michael Reactions.
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DOI: 10.1021/acs.orglett.9b02310
Abstract: Herein, we introduce α-nitro-α,β-unsaturated ketones as efficient electrophilic acyl transfer reagents, and they were employed in Friedel-Crafts as well as in Michael reactions. The desired acyl transfer products of these reactions were obtained in high… read more here.
Keywords: electrophilic acyl; acyl transfer; unsaturated ketones; michael reactions ... See more keywords
Divergent and Diastereoselective Synthesis of α-Monosubstituted and trans-α,β-Disubstituted γ-Lactams from (S)-N,N-Dibenzyl-α-amino Aldehydes via Henry and Michael Reactions
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DOI: 10.1055/s-0040-1706423
Abstract: γ-Monosubstituted and trans-α,β-disubstituted γ-lactams were diastereoselectively synthesized from common intermediates (S)-N,N-dibenzylated aldehydes derived from natural l -(α)-amino acids, employing a divergent approach. The key features of the routes include diastereoselective Henry and Michael reactions that… read more here.
Keywords: amino; michael reactions; trans disubstituted; henry michael ... See more keywords