The Interaction of Factor Xa and IXa with Non-Activated Antithrombin in Michaelis Complex: Insights from Enhanced-Sampling Molecular Dynamics Simulations
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DOI: 10.3390/biom13050795
Abstract: The interaction between coagulation factors Xa and IXa and the activated state of their inhibitor, antithrombin (AT),have been investigated using X-ray diffraction studies. However, only mutagenesis data are available for non-activated AT. Our aim was… read more here.
Keywords: dynamics simulations; sampling molecular; molecular dynamics; interaction factor ... See more keywords