Estimating kinetic constants in the Michaelis–Menten model from one enzymatic assay using Approximate Bayesian Computation
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13531
Abstract: The Michaelis–Menten equation is one of the most extensively used models in biochemistry for studying enzyme kinetics. However, this model requires at least a couple (e.g., eight or more) of measurements at different substrate concentrations… read more here.
Keywords: kinetic constants; michaelis menten; estimating kinetic; enzymatic assay ... See more keywords
Dynamics analysis of stochastic modified Leslie–Gower model with time-delay and Michaelis–Menten type prey harvest
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Mathematics and Computing"
DOI: 10.1007/s12190-021-01612-y
Abstract: In this paper, we study the dynamics of stochastic time-delayed predator–prey model with modified Leslie–Gower and ratio-dependent schemes including additional food for predator and prey with Michaelis–Menten type harvest. We introduce the effects of time… read more here.
Keywords: prey; michaelis menten; system; time ... See more keywords
Stability and Bifurcation in a Prey–Predator–Scavenger System with Michaelis–Menten Type of Harvesting Function
Sign Up to like & getrecommendations! Published in 2019 at "Differential Equations and Dynamical Systems"
DOI: 10.1007/s12591-018-00449-5
Abstract: In this paper an ecological model consisting of prey–predator–scavenger involving Michaelis–Menten type of harvesting function is proposed and studied. The existence, uniqueness and uniformly bounded of the solution of the proposed model are discussed. The… read more here.
Keywords: michaelis menten; prey predator; predator scavenger; stability ... See more keywords
Prey–Predator Dynamics with Two Predator Types and Michaelis–Menten Predator Harvesting
Sign Up to like & getrecommendations! Published in 2019 at "Differential Equations and Dynamical Systems"
DOI: 10.1007/s12591-019-00500-z
Abstract: We consider the population dynamics of prey under the effect of the two types of predators. One of the predator types is harvested, modelled with a term with a Michaelis–Menten type functional form. Besides local… read more here.
Keywords: michaelis menten; prey predator; dynamics two; predator dynamics ... See more keywords
Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.08.017
Abstract: Abstract The widespread applications of the century-old Michaelis-Menten kinetics in the characterization of drug-metabolizing cytochrome P450 enzymes have persisted since their discovery in the 1950s. This is a concern given preceding reports of atypical Michaelis-Menten… read more here.
Keywords: michaelis menten; menten kinetics; cytochrome p450; p450 enzymes ... See more keywords
Numerical analysis of apparent decitabine uptake in HCT116 cells: Incorporation of a bidirectional first-order kinetic parameter for ENT1 transport and Michaelis-Menten parameters for subsequent phosphorylation.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.10.002
Abstract: Decitabine (DAC), a DNA methylation inhibitor, is transported into cancer cells mainly via equilibrative nucleoside transporter 1 (ENT1) and subsequently phosphorylated by deoxycytidine kinase (dCK). We previously reported that apparent DAC uptake into cells may be… read more here.
Keywords: michaelis menten; hct116 cells; menten parameters; subsequent phosphorylation ... See more keywords
Impact of capillary flow hydrodynamics on carrier‐mediated transport of opioid derivatives at the blood‐brain barrier, based on pH‐dependent Michaelis‐Menten and Crone‐Renkin analyses
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.06.016
Abstract: Abstract Most studies of blood‐brain barrier (BBB) permeability and transport are conducted at a single pH, but more detailed information can be revealed by using multiple pH values. A pH‐dependent biophysical model was applied to… read more here.
Keywords: blood brain; michaelis menten; transport; hydrodynamics ... See more keywords
Noise slows the rate of Michaelis–Menten reactions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2017.06.039
Abstract: Microscopic randomness and the small volumes of living cells combine to generate random fluctuations in molecule concentrations called "noise". Here I investigate the effect of noise on biochemical reactions obeying Michaelis-Menten kinetics, concluding that substrate… read more here.
Keywords: noise slows; michaelis menten; reaction; menten reactions ... See more keywords
An alternative approach to Michaelis-Menten kinetics that is based on the renormalization group.
Sign Up to like & getrecommendations! Published in 2018 at "Mathematical biosciences"
DOI: 10.1016/j.mbs.2017.11.012
Abstract: We apply to Michaelis-Menten kinetics an alternative approach to the study of Singularly Perturbed Differential Equations, that is based on the Renormalization Group (SPDERG). To this aim, we first rebuild the perturbation expansion for Michaelis-Menten… read more here.
Keywords: renormalization group; michaelis menten; alternative approach; menten kinetics ... See more keywords
Michaelis-Menten kinetics of soil respiration feedbacks to nitrogen deposition and climate change in subtropical forests
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DOI: 10.1038/s41598-017-01941-8
Abstract: China experiences some of the highest rates of anthropogenic nitrogen deposition globally, with further increases projected. Understanding of soil feedbacks to the combined anthropogenic influences of climate change and nitrogen deposition in these systems is… read more here.
Keywords: michaelis menten; nitrogen deposition; deposition; climate change ... See more keywords
Bifurcation analysis in a diffusive predator–prey system with Michaelis–Menten-type predator harvesting
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Difference Equations"
DOI: 10.1186/s13662-018-1741-5
Abstract: In this paper, we consider a modified predator–prey model with Michaelis–Menten-type predator harvesting and diffusion term. We give sufficient conditions to ensure that the coexisting equilibrium is asymptotically stable by analyzing the distribution of characteristic… read more here.
Keywords: predator prey; michaelis menten; bifurcation; predator ... See more keywords