The essential cysteines in the CIPC motif of the thioredoxin-like Trypanosoma brucei MICOS subunit TbMic20 do not form an intramolecular disulfide bridge in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2022.111463
Abstract: The mitochondrial protein import machinery of trypanosomatids is highly divergent from that of the well-studied models such as baker's yeast. A notable example is that the central catalyst of the mitochondrial intermembrane space import and… read more here.
Keywords: disulfide; form; micos; intramolecular disulfide ... See more keywords
Abstract 270: Micu1 Regulates Mitochondrial Structural Integrity and Cristae Function Independent of Mcu Calcium Uptake
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DOI: 10.1161/res.127.suppl_1.270
Abstract: MICU1 is a Ca 2+ -sensor regulating the mitochondrial Ca 2+ uniporter channel (mtCU) and mitochondrial Ca 2+ uptake. MICU1 contains two Ca 2+ - binding EF-hand domains and directly interacts with the mtCU pore-forming… read more here.
Keywords: cristae; micos; mcu; regulates mitochondrial ... See more keywords
Drosophila MIC10b can polymerize into cristae-shaping filaments
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DOI: 10.26508/lsa.202302177
Abstract: DmMIC10b, the primary MIC10 orthologue in Drosophila, is crucial for MICOS stability and mitochondrial ultrastructure and exhibits a distinctive ability to form filaments, impacting mitochondrial cristae architecture. Cristae are invaginations of the mitochondrial inner membrane… read more here.
Keywords: micos; mic10b polymerize; cristae; mic10 ... See more keywords
Lifespan Extension of Podospora anserina Mic60-Subcomplex Mutants Depends on Cardiolipin Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094741
Abstract: Function of mitochondria largely depends on a characteristic ultrastructure with typical invaginations, namely the cristae of the inner mitochondrial membrane. The mitochondrial signature phospholipid cardiolipin (CL), the F1Fo-ATP-synthase, and the ‘mitochondrial contact site and cristae… read more here.
Keywords: longevity; podospora anserina; micos; subcomplex mutants ... See more keywords