Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states
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DOI: 10.1371/journal.pcbi.1009977
Abstract: The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of allostery in dynamic… read more here.
Keywords: allostery dynamic; molecular recognition; coactivator; micro states ... See more keywords